Home
Research
Overview
Publications
People
Profiles
Group Photos
Alumni
How to Reach Us
Contact Info
Lab directory
Directions
|
Search PubMed for Lodish lab articles
1994 | 1995
| 1996 | 1997 | 1998
| 1999 | 2000 | 2001
| 2002 | 2003 | 2004
| 2005 | 2006 | 2007
| 2008 | 2009 | 2010
| 2011 |
2012 | 2013
Longmore, G.D., P.N. Pharr,
and H.F. Lodish. A
constitutively erythropoietin receptor stimulates proliferation
and induces transformation of multipotent, committed nonerythroid
and erythroid progenitor cells. Molecular & Cell.
Biol. 14: 2266-2277 (1994). |
Watowich, S. S., D. J. Hilton,
H. F. Lodish. Activation
and inhibition of erythropoietin receptor function: Role of
receptor dimerization. Mol. & Cell. Biol. 14:
3535-3549 (1994). |
Bhushan, A., H.Y. Lin, H.F.
Lodish and C.R. Kintner. The
transforming growth factor beta type II receptor can replace
the activin type II receptor in inducing mesoderm. Mol.
& Cell. Biol. 14: 4280-4285 (1994). |
Henis, Y. I., A. Moustakas,
H. Y. Lin, and H. F. Lodish. The
Type II and Type III transforming growth factor-beta receptors
form homo-oligomers. J. Cell Biol. 126: 139-154
(1994) . |
Acton, S. L., P. E. Scherer,
H. F. Lodish and M. Krieger. Expression
cloning of SR-BI, a CD36-related class B scavenger receptor.
J. Biol. Chem. 269: 21003-21009 (1994). |
Schaffer, J. and H. F. Lodish.
Expression
cloning and characterization of a novel adipocyte long chain
fatty acid transport protein. Cell 79: 427-436
(1994). |
Chun, M., U. K. Liyanage, M.
P. Lisanti, and H. F. Lodish. Signal
transduction of a G-protein coupled receptor in caveolae:
Colocalization of endothelin and its receptor with caveolin.
Proc. Natl. Acad. Sci. USA. 91: 11728-11732 (1994). |
Takumi, T. and H. F. Lodish.
Rapid
cDNA cloning by PCR screening (RC-PCR). BioTechniques
17: 443-444 (1994). |
Scherer, P. E., M. P. Lisanti,
G. Baldini, M. Sargiacomo, C. C. Mastick, and H. F. Lodish.
Induction
of caveolin during adipogenesis and association of GLUT4 with
caveolin-rich vesicles. J. Cell Biol. 127: 1233-1243
(1994). |
Efrat, S., M. Tal, and H. F.
Lodish. The
pancreatic beta-cell glucose sensor. Trends in Biochemical
Sciences 19: 535-538 (1994). |
Simonsen, H. and H. F. Lodish.
Cloning
by function: expression cloning in mammalian cells. Trends
in Pharmacological Sciences 15: 437-441 (1994). |
Hilton, D. J., S. S. Watowich,
P. J. Murray, and H. F. Lodish. Increased
cell surface expression and enhanced folding in the endoplasmic
reticulum of a mutant erythropoietin receptor. Proc.
Natl. Acad. Sci. USA. 92: 190-194 (1995). |
Moustakas, A., T. Takumi, H.
Y. Lin, and H. F. Lodish. GH3
Pituitary tumor cells contain heteromeric type I and type
II receptor complexes for transforming growth factor beta
and activin A. J. Biol. Chem. 270: 765-769 (1995). |
Takumi, T., A. Moustakas, H.
Y. Lin, and H. F. Lodish. Molecular
characterization of a type I serine-threonine kinase receptor
for TGF-beta and activin in the rat pituitary tumor cell line
CH3. Experimental Cell Research.216: 208-214 (1995). |
Lin, H. Y., A. Moustakas, P.
Knaus, R. G. Wells, Y. I. Henis, and H. F. Lodish. The
soluble exoplasmic domain of the type II transforming growth
factor (TGF)-beta receptor. J. Biol. Chem. 270:
2747-2754 (1995). |
Klingmueller, U., U. Lorenz,
L. C. Cantley, B. G. Neel, and H. F. Lodish. Specific
recruitment of SH-PTP1 to the erythropoietin receptor causes
inactivation of JAK2 and termination of proliferative signals.
Cell. 80: 729-738 (1995). |
Lodish, H. F., D. Baltimore,
A. Berk, L. Zipursky, P. Matsudaira, and J. E. Darnell. Molecular
Cell Biology, 3rd ed. Scientific American Press, N.Y.
(1995). |
Baldini, G., P. E. Scherer,
and H. F. Lodish. Nonneuronal
expression of Rab3A: Induction during adipogenesis and association
with different intracellular membranes than Rab3D. Proc.
Natl. Acad. Sci. USA. 92: 4284-4288 (1995). |
Chun, M., H. Y. Lin, Y. I. Henis,
and H. F. Lodish. Endothelin-induced
endocytosis of cell surface ETA receptors: Endothelin remains
intact and bound to the ETA receptor. J. Biol. Chem.
270: 10855-10860 (1995). |
Scherer, P. E., Z. Tang, M.
Chun, M. Sargiacomo, H. F. Lodish, and M. P. Lisanti. Caveolin
isoforms differ in their N-terminal protein sequence and subcellular
distribution: Identification and epitope mapping of an isoform-specific
monoclonal antibody probe. J. Biol. Chem. 270:
16395-16401 (1995). |
Rodriguez, C., F. Chen, R. Weinberg,
and H. F. Lodish. Cooperative
binding of TGF-beta2 to the types I and II TGF-beta receptors.
J. Biol. Chem.: 270 15919-15922 (1995). |
Yuk, M. H. and H. F. Lodish.
Enhanced
folding and processing of a disulfide mutant of the human
asialoglycoprotein receptor H2b subunit. J. Biol. Chem.270
20169-20176 (1995). |
Murray, P. J., S. S. Watowich,
H. F. Lodish, R. A. Young, and D. J. Hilton. Epitope
tagging of the human endoplasmic reticulum HSP70 protein,
BiP, to facilitate analysis of BiP-substrate interactions.
Anal. Biochem. 229: 170-179 (1995) |
Wu, H., U. Klingmueller, and
H. F. Lodish. Physical
and functional interaction of the erythropoietin and stem
cell factor receptors. Nature 377: 242-246 (1995). |
Wu, H., X. Liu, R. Jaenisch,
and H. F. Lodish. Generation
of committed erythroid BFU-E and CFU-E progenitors does not
require erythropoietin or erythropoietin receptor. Cell
83: 59-67 (1995). |
Martelli, A. M., R. Bareggi,
G. Baldini, P. E. Scherer, H. F. Lodish, and G. Baldini. Diffuse
vesicular distribution of Rab3D in the polarized neuroendocrine
cell line AtT-20. FEBS Letters 368: 271-275 (1995). |
Chen, K., G. N. Stephanopoulos,
A. J. Sinskey, and H. F. Lodish. Regulated
secretion of prolactin by the mouse insulinoma cell line betaTC-3.
BioTechnology 13; 1191-1197 (1995) |
Hwang, C., H. F. Lodish, and
A. J. Sinskey. Measurement
of glutathione redox state in cytosol and secretory pathway
of cultured cells. Methods in Enzymology 251: 212-221
(1995). |
Scherer, P. E., S. Williams,
M. Fogliano, G. Baldini, and H. F. Lodish. A
novel serum protein similar to C1q, produced exclusively in
adipocytes. J. Biol. Chem. 270: 26746-26749 (1995). |
Schaffer, J. E. and H. F. Lodish.
Molecular mechanism of long chain fatty acid uptake. Trends
in Cardiovascular Medicine 5: 218-224 (1995). |
Luo, K., P. Zhou, and H. F.
Lodish. The
specificity of the transforming growth factor beta receptor
kinases determined by a spatially addressable peptide library.
Proc. Natl. Acad. Sci. USA. 92: 11761-11765. (1995) |
Tang, Z.L., P. E. Scherer, T.
Okamoto, K. Song, C. Chu, D. S. Kohtz, I. Nishimoto, H. F.
Lodish, and M. P. Lisanti. Molecular
cloning of caveolin-3, a novel member of the caveolin gene
family expressed predominantly in muscle. J. Biol.
Chem.271: 2255-2261 (1996). |
Scherer, P. E., T. Okamoto,
M. Chun, I. Nishimoto, H. F. Lodish, and M. P. Lisanti. Identification,
sequence and expression of caveolin-2 defines a caveolin gene
family. Proc. Natl. Acad. Sci. USA. 93: 131-135.
(1996). |
Hilton, D. J., S. S. Watowich,
L. Katz, and H. F. Lodish Saturation
mutagenesis of the WSXWS motif of the erythropoietin receptor.
J. Biol. Chem. 271: 4699-4708 (1996). |
Cohen, N. R., D. A. Knecht,
and H. F. Lodish. Functional
expression of rat glut 1 glucose transporter in Dictyostelium
discoideum. Biochemical J. 315: 971-975 (1996). |
Neumann, D., H. F. Lodish, M.
H. Yuk, and G. Z. Lederkremer. Blocking
intracellular degradation of the erythropoietin and asialoglycoprotein
receptors by calpain inhibitors does not result in the same
increase in the levels of their membrane and secreted forms.
Biochemical J. 313: 391-399 (1996). |
Scherer, P. E., G. Z. Lederkremer,
S. Williams, M. Fogliano, G. Baldini, and H. F. Lodish. Cab45,
a novel Ca2+-binding protein localized to the Golgi lumen.
J. Cell Biology 133: 257-268 (1996). |
Lodish, H. F., D. J. Hilton,
U. Klingmueller, S. Watowich, and H. Wu. The
erythropoietin receptor: biogenesis, dimerization, and intracellular
signal transduction. Cold Spring Harbor Symposium.
Vol 60: 93-104.(1996) |
Tolchinsky, S., M. H. Yuk, M.
Ayalon, H. F. Lodish, and G. Z. Lederkremer. Membrane-bound
versus secreted forms of human asialoglycoprotein receptor
subunits. J. Biol. Chem. 271: 14496-14503 (1996). |
Knaus, P. I., D. Lindemann,
J. F. DeCoteau, R. Perlman, H. Yankelev, M. Brooks, M. Hille,
M. E. Kadin, and H. F. Lodish. A
dominant inhibitory mutant of the type II TGF-beta receptor
in the malignant progression of a cutaneous T-cell lymphoma.
Mol. Cell Biol. 16: 3480-3489 (1996). |
Mann, M. Z., T. Y. Hui, J. E.
Schaffer, H. F. Lodish, and D. A. Bernlohr. Regulation
of the murine adipocyte fatty acid transporter gene by insulin.
Molecular Endocrinology 10: 1021-1028 (1996). |
Klingmueller, U., S. Bergelson,
J. G. Hsiao, and H. F. Lodish. Multiple
tyrosine residues in the cytosolic domain of the erythropoietin
receptor promote activation of STAT5. Proc. Nat. Acad.
Sci. USA. 93: 8324-8328 (1996). |
Luo, K. and H. F. Lodish Signaling
by chimeric erythropoietin-TGF-beta Receptors: Dimerization
of the type I TGF-beta receptor cytoplasmic domain is required
for intracellular signal transduction. EMBO Journal
15: 4485-4496 (1996). |
Watowich, S. S., H. Wu, M. Socolovsky,
U. Klingmueller, S. Constantinescu, and H. F. Lodish. Cytokine
receptor signal transduction and the control of hematopoietic
cell development. Ann. Rev. Cell. Biol. 12: 91-128
(1996). |
Wu, H., U. Klingmueller, A.
Acurio, J. G. Hsiao, and Lodish, H. F. Functional
interaction of erythropoietin and stem cell factor receptors
is essential for erythroid colony formation. Proc.
Natl. Acad. Sci. USA 94: 1806-1810 (1997). |
Klingmueller, U., H. Wu, J.
G. Hsiao, A. Toker, B. C. Duckworth, L. C. Cantley, and H.
F. Lodish. Identification
of a novel pathway important for proliferation and differentiation
of primary erythroid progenitors. Proc. Natl. Acad.
Sci. USA 94: 3016-3021 (1997). |
Wells, R. G., H. Yankelev, H.
Lin, and H. F. Lodish Biosynthesis
of the type I and type II TGF-beta receptors: Implications
for complex formtion. J. Biol. Chem. 272: 11444-11451
(1997). |
Bickel, P., P. E. Scherer, J.
E. Schnitzer, P. Oh, M. P. Lisanti, and H. F. Lodish. Flotillin
and ESA define a new family of caveolae-associated integral
membrane proteins. J. Biol. Chem. 272: 13793-13802
(1997). |
Socolovsky, M., I. Dusanter-Fourt,
and H. F. Lodish. The
prolactin receptor and severely truncated erythropoietin receptors
support differentiation of committed erythroid progenitors.
J. Biol. Chem. 272: 14009-14012 (1997). |
Luo, K. and H. F. Lodish. Positive
and negative regulation of type II TGF-beta receptor signal
transduction by autophosphorylation on multiple serine residues.
EMBO Journal 16: 1970-1981 (1997). |
DeCoteau, J. F., P. I. Knaus,
H. Yankelev, M. D. Reis, R. Lowsky, H. F. Lodish, and M. E.
Kadin. Loss
of functional cell surface Transforming Growth Factor beta
(TGF-beta) type I receptor correlates with insensitivity to
TGF-beta in chronic lymphocytic leukemia. Proc. Natl.
Acad. Sci. USA 94: 5877-5881 (1997). |
Liu, X., Y. Sun, S. N. Constantinescu,
E. Karam, R. A. Weinberg, and H. F. Lodish. TGF-beta-induced
phosphorylation of Smad3 is required for growth inhibition
and transcriptional induction in epithelial cells. Proc.
Natl. Acad. Sci. USA 94: 10669-10674 (1997). |
Bergelson, S., U. Klingmueller,
M. Socolovsky, J. Hsiao, and H. F. Lodish. Tyrosine
residues within the intracellular domain of the erythropoietin
receptor mediate activation of AP-1 transcription factors.
J. Biol. Chem. 273: 2396-2401 (1998) |
Brink, R. and H. F. Lodish.
Tumor
necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A),
a TRAF2 splice variant with an extended RING finger domain
that inhibits TNFR2-mediated NF-kB activation. J. Biol.
Chem. 273: 4129-4134 (1998). |
Constantinescu, S., H. Wu, X.
Liu, W. Beyer, A. Fallon, and H. F. Lodish. The
Anemic Friend Virus gp55 envelope protein induces erythroid
differentiation in fetal liver CFU-Es. Blood 91:
1163-1172 (1998). |
Gilboa, L., R. G. Wells, H.
F. Lodish, and Y. I. Henis. Oligomeric
Structure of Type I and Type II TGF-beta Receptors: Homo-dimers
form at the ER and persist at the plasma membrane. J.
Cell Biol. 140: 767-777 (1998) |
Rodriguez, C. and H. F. Lodish.
Enhanced
efficiency of cloning FACS-sorted mammalian cells. Biotechniques
24: 750-752 (1998) |
Socolovsky, M., H. F. Lodish,
and G. Q. Daley. Control
of hematopoietic differentiation: Lack of specificity in signaling
by cytokine receptors. Proc. Natl. Acad. Sci. USA.
95: 6573-6575 (1998) |
Scherer, P. E., P. E. Bickel,
M. Kotler, and H. F. Lodish. Cloning
of cell-specific and surface proteins by subtractive antibody
screening. Nature Biotechnology 16: 581-586. |
Hirsch, D. J., A. Stahl, and
H. F. Lodish. A
family of fatty acid transporters conserved from mycobacterium
to man. Proc. Natl. Acad. Sci. USA 95: 8625-8629
(1998). |
Socolovsky, M., A. Fallon, and
H. F. Lodish. The
prolactin receptor rescues Epo-R-/-Erythroid progenitors and
replaces EpoR in a synergistic interaction with c-kit.
Blood. 92: 1491-1496 (1998). |
Socolovsky, M., S. N.
Constantinescu, S. Bergelson, A. Sirotkin, and H. F. Lodish.
Cytokines in Hematopoiesis: Specificity and Redundancy in
Receptor Function. In Advances in Protein Chemistry,
J. Wells, ed. 52: 142-199. (1998) |
Hua, Xianxin, X. Liu, D.O. Ansari,
and H.F. Lodish. Synergistic
cooperation of TFE3 and Smad proteins in TGF-beta-induced
transcription of the plasminogen activator inhibitor- 1 gene.
Genes and Development. 12: 3084-3095 (1998). |
Lin, R. S., C. Rodriguez, A.
Veillette, and H. F. Lodish. Zinc
is essential for binding of p56lck to CD4 and CD8alpha.
J. Biol. Chemistry 273: 32878-32882 (1998) |
S. N. Constantinescu, S. Ghaffari and H.
F.Lodish. Erythropoietin receptor: Structure, activation,
and intracellular signal transduction. Trends in Endocrinology
and Metabolism 10: 18-23 (1999). |
Wells, R.G., L. Gilboa, Y. Sun, X. Liu, and
H.F. Lodish. TGF-beta
induces formation of a DTT-resistant type I / type II receptor
complex in live cells. J. Biol. Chemistry. 274:
5716- 5722 (1999). |
Bogan, J. S., and H. F. Lodish. Two
compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes
defined by endogenous GLUT4 and ACRP30. J. Cell Biol.,
146: 609 - 620 (1999) |
Constantinescu, S. N., X. Liu, W. Beyer,
A. Fallon, S. Shekar, S. O. Smith, and H. F. Lodish. Activation
of the murine erythropoietin receptor by a viral envelope
protein involves specific interactions within transmembrane
domains. EMBO J, 18: 3334- 3358 (1999). |
Chatterton, J. E., D. Hirsch, J. J. Schwartz,
P. E. Bickel, R. D. Rosenberg, H. F. Lodish and M. Krieger.
Expression
Cloning of LDLB, a Gene Essential for Normal Golgi Function
and Assembly of a Novel Protein Complex. Proc. Natl.
Acad. Sci. USA 96: 915 - 920 (1999). |
Ghaffari, Saghi, G. Q. Daley, and H. F. Lodish.
Growth
factor independence and BCR/ABL transformation: Promise and
pitfalls of available assays. Leukemia. Invited review
Leukemia, 13: 1200- 1206 (1999). |
Socolovsky, M., A. E. J. Fallon, S. Wang,
C. Brugnara, and H. F. Lodish. Fetal
anemia and apoptosis of red-cell progenitors in Stat5a-/-Stat5b-/-
mice: a direct role for Stat5 in bcl-x - induction. Cell.
98: 181- 192 (1999). |
Schiemann, W. P., W. M. Pfeifer, M. E. Kadin,
and H. F. Lodish. A
deletion in the gene for the transforming growth factor b
type I receptor that abolishes its expression in a new human
cutaneous T-cell lymphoma cell line. Blood, 94:
2854 - 2861 (1999). |
Sun, Y., X. Liu, E. Ng Eaton, W. S. Lane,
H. F. Lodish, and R. A. Weinberg. Interaction
of the Ski Oncoprotein with Smad3 Regulates TGF-b Signaling.
Molecular Cell, 4: 499 &endash; 508 (1999). |
Hua, X., Z. Miller, G. Wu, Y. Shi, and H.
F. Lodish. Specificity
in TGF-beta-Induced Transcription of the Plasminogen Activator
Inhibitor-1 Gene: Interactions of Promoter DNA, Smad3, and
TFE3. Proc. Natl. Acad. Sci. USA, 96: 13130 - 13135
(1999). |
Stahl, A., D. J. Hirsch, R. Gimeno, S. Punreddy,
P. Ge, N. Watson, S. Patel, M. Kotler, A. Raimondi, L. A.
Tartaglia, and H. F. Lodish. Identification
of the major intestinal fatty acid transport protein.
Molecular Cell, 4: 299 - 308 (1999). |
Sun, Y., X. Liu, E. Ng Eaton, H. F. Lodish,
and R. A. Weinberg. SnoN
and Ski Protooncoproteins are rapidly degraded in response
to TGF-b signalling. Proc. Natl. Acad. Sci. USA, 96:
12442 - 12447 (1999). |
Lodish, H. F., A. Berk, L. Zipursky, P. Matsudaira,
D. Baltimore, and J. E. Darnell. Molecular Cell Biology,
4th ed. Scientific American Press, N.Y. (1999). |
Ghaffari, S. H. Wu, K. M. Gerlach, Y. Han,
H. F. Lodish, and G. Q. Daley. BCR-ABL
and v-SRC tyrosine kinase oncoproteins support normal erythroid
development in erythropoietin receptor-deficient progenitor
cells. Proc. Natl. Acad. Sci. USA 96: 13186 - 13190
(1999).
|
Pandey, A., A.
V. Podtelejnikov, B. Blagoev, X. R. Bustelo, M. Mann, and
H. F. Lodish. Analysis
of receptor signaling pathways by mass spectrometry: Identification
of Vav-2 as a novel substrate of the epidermal and platelet-derived
growth factor receptors. Proc. Natl. Acad. Sci. USA
97: 179 - 184 (2000).
Brooks, C., P. Scherer, K. Cleveland,
J. Whittemore, H. F. Lodish, and B. Cheatham. Pantophysin
is a phosphoprotein component of adipocyte transport vesicles
and associates with GLUT4- containing vesicles. J.
Biol. Chem. 275: 2029 - 2036 (2000)
Liu, X., S. Constantinescu,, Y. Sun, J. S. Bogan, D. Hirsch,
R. A. Weinberg,, and H. F. Lodish. Generation
of mammalian cells stably expressing multiple genes at predetermined
levels. Anal. Biochem. 280: 20-28 (2000).
Blobe, G.C., W. P. Schiemann, and H. F. Lodish. Role
of Transforming Growth Factor ?in human disease. New
Engl. Jour. Med. 342: 1350-1359 (2000).
Xiao, Z., X. Liu, Y. Henis, and H. F. Lodish. A
distinct nuclear localization signal in the MH1 domain of
Smad3 determines its ligand-induced nuclear translocation.
Proc. Natl. Acad. Sci. USA 97: 7853 - 7858 (2000).
Xiao, Z., X. Liu, and H. F. Lodish.
Importin
beta Mediates Nuclear Translocation of Smad 3. J. Biol.
Chem. 275: 23425 - 23428 (2000)
Pandey, A., K. Ozaki, H. Baumann,
S. D. Levin, A. G. Farr, S. F. Ziegler, W. J. Leonard, and
H. F. Lodish. Cloning
of a novel receptor subunit required for signaling by Thymic
Stromal Lymphopoietin. Nature Immunology 1: 59-64
(2000).
Yamamura, Y., X. Hua, S. Bergelson,
and H. F. Lodish. Critical
Role of Smads and AP-1 Complex in TGF-?Dependent Apoptosis.
J. Biol. Chem. 275: 36295 - 36302 (2000)
Hua, X., Z. Miller, H. Benchabane,
J. Wrana, and H. F. Lodish. Synergism
between transcription factors TFE3 and Smad 3 in TGF-?induced
transcription of the Smad 7 gene. J. Biol. Chem. 275:
33205 - 33208 (2000)
Chi, N-W and H. F. Lodish Tankyrase
is a Golgi-associated MAP Kinase substrate that interacts
with IRAP in GLUT4 vesicles J. Biol. Chem. 275: 38437
- 38444 (2000)
Pandey, A., M. Fernandez, H. Steen,
B. Blagoev, M. Nielsen, S. Roche, M. Mann, and H. F. Lodish.
Identification
of an immunoreceptor tyrosine-based activation motif (ITAM)
- containing molecule, STAM2, by mass spectrometry and its
involvement in growth factor and cytokine receptor signaling
pathways. J. Biol. Chem. 275: 38633 - 38639 (2000)
Liu, X., Y. Sun, M. Ehrlich, T.
Lu, Y. Kloog, R. A. Weinberg, H. F. Lodish, and Y. I. Henis.
Disruption
of TGF-?Growth Inhibition by Oncogenic Ras is Linked to p27Kip1
Mislocalization Oncogene 19: 5926 - 5935 (2000)
Bickel, P., H. F. Lodish, and P.
Scherer. Use and Applications of Subtractive Antibody Screening.
Biotechnology and Genetic Engineering Reviews. Vol. 17, Steven
Harding, ed. pp 417 - 430 (2000). |
Constantinescu, S., L. Huang,
H-S Nam, and H. F. Lodish. The
Erythropoietin Receptor Cytosolic Juxtamembrane Domain Contains
an Essential, Precisely Oriented, Hydrophobic Motif. Mol.
Cell 7: 377 - 385 (2001) |
Liu, X., Y. Sun, R. A. Weinberg
and H. F. Lodish. Ski/Sno
and TGF-?Signaling Cytokine and Growth Factor Reviews
12: 1- 8 (2001) |
Fruebis, J., Tsao, T-S., Erickson,
M. R., Lee, L., Yen, F., Bihain, B. E., and Lodish, H. F.
A
Proteolytic Cleavage Product of ACRP30 Increases Fatty Acid
Oxidation in Muscle and Causes Weight Loss in Mice. Proc.
Natl. Acad. Sci. USA 98: 2005 - 2010; (2001) |
Constantinescu, S. N., T. Keren,
M. Socolovsky, H-s Nam, Y. I. Henis and H. F. Lodish Ligand-Independent
Oligomerization of Cell-Surface Erythropoietin Receptor Is
Mediated by the Transmembrane Domain Proc. Natl. Acad.
Sci. USA 98: 4379 - 4384 (2001) |
Perlman, R., W. P. Schiemann,
M. W. Brooks, H. F. Lodish and R. A. Weinberg. TGF-?induced
apoptosis is mediated by the adapter protein Daxx that facilitates
JNK activation Nature Cell Biology 3: 708 - 714 (2001).
|
Bogan, J. B., A. E. McKee, and
H. F. Lodish. Insulin-responsive
compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation
by amino acid concentrations. Mol. Cell Biol. 21: 4785
– 4806 (2001) |
Blobe, G. C.,W. P. Scheimann,
M.-C. Pepin, M. Beauchemin, A. Moustakas, H. F. Lodish. and
M. D. O’Connor-McCourt. Functional
Roles for the Cytoplasmic Domain of the Type III TGF-?Receptor
in Transforming Growth Factor ?Signaling J. Biol. Chem.
276: 24627 - 24637 (2001) |
Stahl, A., R. E. Gimeno, L.
A. Tartaglia, and H. F. Lodish. Fatty
acid transport proteins: A current view of a growing family.
Trends in Endocrinology and Metabolism 12: 266 – 273
(2001) |
Rodriguez, C., J.-S. L. Huang,
J. K. Son, A. McKee, Z. Xiao and H. F. Lodish. Functional
cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding
antagonist of TGF-?signaling. J. Biol. Chem. 276: 30224
- 30230 (2001) |
Xiao, Z., Watson, N., Rodriguez,
C., and H. F. Lodish. Nucleocytoplasmic
shuttling of Smad1 conferred by its nuclear localization and
nuclear export signals. J. Biol. Chem. 276: 39404 - 39410
(2001) |
Ghaffari, S., C. Kitidis, M.
D. Fleming, H. Neubauer, K. Pfeffer, and H. F. Lodish.
Erythropoiesis in the Absence of Janus-kinase 2: BCR-ABL Induces
Red Cell Formation in JAK2-/- Progenitors. Blood 98: 2948-2957
(2001) |
Socolovsky, M., H-S. Nam, M.D.
Fleming, V. H. Haase C. Brugnara and H. F. Lodish Ineffective
Erythropoiesis in Stat5a-/-5b-/- mice due to decreased survival
of early erythroblasts Blood 98: 3261 - 3273 (2001) |
Blobe, G. C., X. Liu, S. Fang,
T. How, and H. F. Lodish A
novel mechanism for regulating Transforming Growth Factor
?signaling: Functional modulation of Type III TGF-?receptor
expression through interaction with the PDZ domain protein,
GIPC J. Biol. Chem. 276: 39608 - 39617 (2001) |
Huang, L. J-S., S. N. Constantinescu
and H. F. Lodish The
N-terminal Domain of Janus Kinase 2 is Required for Golgi
Processing and Cell Surface Expression of Erythropoietin Receptor.
Mol. Cell 8: 1- 20 (2001) |
Sbodio, J., H. Lodish, and N-W
Chi. Tankyrase-2
oligomerizes with tankyrase-1 and binds to both TRF1 and IRAP.
Biochem. J 361: 451 - 459 (2002) |
Zhao, X., S. Ghaffari, H. Lodish,
V. N. Malashkevich and P. S. Kim. Structure
of the Bcr-Abl Oncoprotein Oligomerization Domain Nature
Structural Biology 9: 117 - 120 (2002) |
Ruan, H., N. Hacohen, T. R.
Golub, L. Van Parijs and H. F. Lodish. Tumor
necrosis factor-a suppresses adipocyte-specific genes and
activates expression of preadipocyte genes in 3T3-L1 adipocytes:
Nuclear Factor-kB activation by TNF-a is obligatory. Diabetes.
51: 1319 - 1336 (2002) |
Stahl, A., Evans, J., Patel,
S., D. Hirsch, and H. F. Lodish.
Insulin causes fatty acid transport protein translocation
and enhanced fatty acid uptake in adipocytes. Devel. Cell
2: 477 - 488 (2002) |
Pandey, A., N. Ibarrola, I.
Kratchmarova , M. Fernandez, S. Constantinescu, O. Ohara,
S. Sawasdikosol , H. F. Lodish, and M. Mann.
A novel Src homology 2 domain-containing molecule, Src-Like
Adapter Protein-2 (SLAP-2), which negatively regulates T cell
receptor signaling. J. Biol. Chem. 277: 19131 - 19138
(2002). |
Kratchmarova, I., D. E. Kalume,
B. Blagoev, P. E. Scherer, A. V. Podtelejnikov, H. Molina,
P. E. Bickel, J. S. Andersen, M. M. Fernandez, J. Bunkenborg,
P. Roepstorff, K. Kristiansen, H. F. Lodish, Matthias Mann,
and A. Pandey. A
Proteomic Approach for Identification of Secreted Proteins
During the Differentiation of 3T3-L1 preadipocytes to Adipocytes
Molecular and Cellular Proteomics 1: 213 - 222 (2002) |
Tsao, T-S, H. Lodish, and J.
Fruebis. ACRP30,
a new hormone controlling fat and glucose metabolism.
E. Jour. Pharm 440: 213 – 221. (2002) |
Schiemann, W., G. C. Blobe,
D. Kalume, A. Pandey, and H. F. Lodish. Context-specific
effects of Fibulin-5 (DANCE/EVEC) on cell proliferation, motility,
and invasion: Induction of Fibulin-5 expression by TGF-b and
effects on protein kinase activation . J. Biol. Chem.
277: 27367 - 27377 (2002). |
Tsao, T-s, H. E. Murrey, C.
Hug, D. H Lee, and H. F. Lodish. Oligomerization
State-Dependent Activation of NF-kB Signaling Pathway by Acrp30.
J. Biol. Chem. 277: 29359-2962. |
Pandey, A., B. Blagoev, I. Kratchmarova,
M. Fernandez, M. Nielsen, T. Kristiansen, O. Ohara, A. Podtelejnikov,
S. Roche, H. F. Lodish, and M. Mann. Cloning
of a novel phosphotyrosine binding domain containing molecule,
Odin, involved in signaling by receptor tyrosine kinases.
Oncogene. 21: 8029 - 8036 (2002) |
Ruan, H., P. D. G. Miles, C.
M. Ladd, K. Ross, T, R. Golub, J. M. Olefsky and H. F. Lodish.
Profiling
Gene Transcription in vivo Reveals Adipose Tissue as an Immediate
Target of TNF-a: Implications for Insulin Resistance.
Diabetes. 51: 3176-3188 (2002) |
Hug, C. and H. F. Lodish. Diabetes,
Obesity, and Acrp30/ Adiponectin. Biotechniques 33: 654
- 658 (2002) |
Brisken, C., M. Socolovsky,
H. F. Lodish, and R. A. Weinberg. The
signaling domain of the erythropoietin receptor rescues prolactin
receptor-mutant mammary epithelium. Proc. Natl. Acad.
Sci. USA 99: 14241 - 14245 (2002) |
Chen, C-Z; M. Li, D. de Graph,
S, Monti, B. Gttgens, M.-J. Sanchez, E. S Lander, T. R Golub,
A, R. Green,, and H. F Lodish. Identification
of Endoglin as a novel functional marker that defines long-term
repopulating hematopoietic stem cells. Proc. Natl. Acad.
Sci. USA 99: 15468 - 15473 (2002) |
Joost H.G., G.. I. Bell, J.
D. Best, M. J. Birnbaum, M. J. Charron, Y. T. Chen, H. Doege,
D. E. James, H. F. Lodish, K. H. Moley, J. F. Moley, M. Mueckler,
S. Rogers, A. Schurmann, S. Seino S, B. Thorens. Nomenclature
of the GLUT/SLC2A family of sugar/polyol transport facilitators.
Am J Physiol Endocrinol Metab 282:E974 - 976 (2002) |
Thomas, E., T-s Tsao, A, Saha,
H. E. Murrey, C.- c. Zhang, S. I. Itani, H. F. Lodish, and
N. Ruderman. Enhancement
of muscle fatty acid oxidation by globular domain of ACRP30:
inactivation of Acetyl-CoA carboxylase and stimulation of
AMP-activated protein kinase. Proc. Natl. Acad. Sci. USA
99: 16309-16313 (2002) |
Ghaffari S., L. J. S. Huang,
J. Zhang and H. F. Lodish. Erythropoietin Receptor Signaling
Processes, in "Erythropoietins and Erythropoiesis: Molecular,
Cellular, Preclinical, and Clinical Biology", Graham Molineux,
MaryAnn Foote, and Steven Elliott, editors, Birkhauser Publishing,
(2003) (in the press) |
Kettler, R., C. S. Moghraby,
J. G. Hsiao, O. Sandra, H. F. Lodish, and U. Klingm¸ller.
The
cytokine-inducible SH2 domain containing protein CIS negatively
regulates signaling by promoting apoptosis in erythroid progenitor
cells. J. Biol. Chem. 278: 2654 - 2660 (2003) |
Bogan, J., N. Hendon, A. McKee,
T-s Tsao, and H.F. Lodish Functional
cloning of TUG as a regulator of GLUT4 glucose transporter
trafficking. Nature 425: 727 – 733 (2003) |
Ruan, H., H. J. Pownall, and
H. F. Lodish. Troglitazone
antagonizes TNF-a-induced reprogramming of adipocyte gene
expression by inhibiting the transcriptional regulatory functions
of NF-kB J. Biol. Chem. 278: 28181 - 28192 (2003) |
Xiao, Z., R. Latek, and H. F.
Lodish. An
extended bipartite nuclear localization signal in Smad4 is
required for its nuclear import and transcriptional activity
Oncogene. 22:1057 - 1069 (2003) |
Ruan, H. and H. F. Lodish. Insulin
Resistance in Adipose Tissue: Direct and Indirect Effects
of Tumor Necrosis Factor-a. Cytokine and Growth Factor
Reviews 14: 447-455 (2003) |
Gimeno, R. E., A. Ortegon,.
S. Patel, S. Punreddy, P. Ge, Y. Sun, H. F. Lodish, and A.
Stahl. Identification
of a Heart-specific Fatty Acid Transport Protein J. Biol.
Chem. 278: 16039 - 16044 (2003) |
Zhang, J., M. Socolovsky, A.
W. Gross, and H. F. Lodish. Role
of Ras signaling in erythroid differentiation of mouse fetal
liver cells: functional analysis by a flow cytometry-based
novel culture system. Blood 102: 3938 - 3946 (2003) |
Tsao, T-s., E. Tomas, H. E.
Murrey, C. Hug, D. H. Lee, N. B. Ruderman, J. E. Heuser, and
H. F. Lodish. Role
of Disulfide Bonds in Acrp30/Adiponectin Structure and Signaling
Specificity: Different Oligomers Activate Different Signal
Transduction Pathways. J. Biol. Chem. 278: 50810 - 50817
(2003). |
Ghaffari, S., Z. Jagani, C.
Kitidis, H. F. Lodish and R. Khosravi-Far. Cytokines
and BCR-ABL Mediate Suppression of TRAIL-Induced Apoptosis
through Inhibition of FOXO3a Transcription Factor. Proc.
Natl. Acad. Sci. USA 100: 6523 - 6528 (2003). |
Xiao, Z., A. M. Brownawell,
I. G. Macara and H. F. Lodish. A
novel nuclear export signal in Smad1 is essential for its
signaling. J. Biol. Chem. 278: 34245 - 34252 (2003) |
Gimeno, R. E., D. J. Hirsch,
S. Punreddy, Y. Sun, A. M. Ortegon, H. Wu, T. Daniels, A.
Stricker-Krongrad, H. F. Lodish, and A. Stahl. Targeted
Deletion of Fatty Acid Transport Protein-4 Results in Early
Embryonic Lethality. J. Biol. Chem. 278: 49512 –
49516 (2003) |
Constantinescu, S. T. Keren,
W. P. Russ, I. Ubarretxena-Belandia, Y. Malka, K. Kubatzky,
D. M. Engelman, H. F. Lodish and Y. I. Henis. The
Epo Receptor Transmembrane Domain Mediates Complex Formation
with Viral Anemic and Polycythemic gp55 Proteins J. Biol.
Chem. 278: 43755 - 43763 (2003) |
Ruan, H., M. Zarnowski, S. Cushman,
and H. F. Lodish. Standard
isolation of primary adipose cells from mouse epididymal fat
pads induces inflammatory mediators and down-regulates adipocyte-genes.
J. Biol. Chem. 278: 47585 - 47593 (2003) |
Choong, M. L., A. Tan, B. Luo,
and H. F. Lodish A
novel role for proliferin-2 in the ex vivo expansion of hematopoietic
stem cells FEBS Letters 550: 155 – 162 (2003) |
Chen, C-Z., L. Li, M. Li, and
H. F Lodish The
Endoglin(Positive) Sca-1(Positive) Rhodamine(Low) phenotype
defines a near homogeneous population of long–term repopulating
hematopoietic stem cells. Immunity 19: 525 - 533 (2003) |
Zhang, C-C and H. F. Lodish.
Insulin-like
growth factor 2 expressed in a novel fetal liver cell population
is a growth factor for hematopoietic stem cells Blood
103: 2513 - 2521 (2004) |
Lodish, H. F., A. Berk, P. Matsudaira,
C. Kaiser, M. Krieger, M. Scott, L. Zipursky, and J. E. Darnell.
Molecular Cell Biology, 5th ed. Scientific American Press,
N.Y. (2004). |
Chen, C-Z., L. Li, H. F. Lodish,
and D. P. Bartel. MicroRNAs
Modulate Hematopoietic Lineage Differentiation. Science
303, 83-86 (2004) |
Tsao, T-s, C. Hug, and H. F.
Lodish. Adipokines: Regulators of Metabolic Integration and
Energy Metabolism. Chapter 65 in Diabetes Mellitus: A Fundamental
and Clinical Text. Third Edition. D. LeRoith, S. Taylor, and
J. Olefsky eds. Lippincott Williams and Wilkins pp 963 - 978
(2004) |
Luo, B., A. Heard, and H. F.
Lodish. siRNA
production by enzymatic engineering of DNA (SPEED) Proc.
Natl. Acad. Sci. USA 101: 5494 - 5499 (2004) |
Ruan H and H. F. Lodish. Regulation
of insulin sensitivity by adipose tissue-derived hormones
and inflammatory cytokines. Curr Opin Lipidol. 15(3):297-302
(2004). |
Marszalek, J. R., C. Kitidis,
A. Dararutana and H. F. Lodish Acyl
CoA Synthetase 2 (ACS2) Over-expression Enhances Fatty Acid
Internalization and Neurite Outgrowth J. Biol. Chem. 279:
23882 - 23891 (2004). |
Kim, J., R. E. Gimeno, T. Higashimori,
H-J. Kim, H. Cho, ,S. Punreddy, R. Mozell, G. Tan, A. Stricker-Krongrad,
D. J. Hirsch, J. J. Fillmore, Z-X. Liu, J. Dong, G. Cline,
A. Stahl, H. F. Lodish, and G. I. Shulman. Inactivation
of Fatty Acid Transport Protein 1 Prevents Fat-Induced Insulin
Resistance In Skeletal Muscle J. Clinical Investigation
113: 756 - 763 (2004). |
Choong, M. L., B. Luo, and H.
F. Lodish. Microenvironment-
driven changes in the expression profile of hematopoietic
cobblestone area- forming cells. Ann. Hematol. 83:160–169
(2004) |
Choong, M. L., Y. P., Yonga,
A. Tana, B. Luo, and H. F. Lodish. LIX:
a chemokine with a role in hematopoietic stem cells maintenance.
Cytokine 25: 239 – 245 (2004). |
Zhang, J., and H. F. Lodish.
Constitutive
activation of the MEK/ERK pathway mediates all effects of
oncogenic H-ras expression in primary erythroid progenitors.
Blood (2004) |
Hug, C., J. Wang, N. Ahmad,
J. Bogan, T.-S. Tsao, and H. F. Lodish. T-cadherin
is a receptor for hexameric and high molecular weight forms
of Acrp30/adiponectin. Proc. Natl. Acad. Sci. USA (2004) |
Tong, W., and H. F. Lodish.
Lnk
inhibits Tpo/mpl signaling and Tpo-mediate megakaryocytopoiesis.
J. Exp. Med (2004). |
Wong, G., J. Wang, C. Hug, T.-S.
Tsao, and H. F. Lodish. A
family of Acrp30/adiponectin structural and functional paralogs.
Proc. Natl. Acad. Sci. USA (2004) |
|
Marszalek, J., C. Kitidis,
C. DiRusso and H. F. Lodish
Long-chain Acyl CoA Synthetase 6 preferentially promotes
DHA metabolism. J. Biol. Chem. 280: 10817 - 10826 (2005). |
Chen, C-Z., and H. F. Lodish.
microRNAs
as regulators of mammalian hematopoiesis. Semin. Immunol.
17: 155–165 (2005) |
Hug, C. and H. F. Lodish.
The
role of the adipocyte hormone Adiponectin in cardiovascular
disease. Current Opinions in Pharmacology 5: 129 - 134
(2005) |
Zhang, C-C. and H. F. Lodish.
Murine
hematopoietic stem cells change their surface phenotype
during ex vivo expansion. Blood 105: 4314 - 4320 (2005). |
Zhang, J. and H. F. Lodish.
Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo. . Proc. Natl. Acad. Sci. 102: 14605- 14610 (2005) . |
Marszalek, J., and H. F. Lodish.
Docosahexaenoic Acid, Fatty Acid Interacting Proteins, and
Neuronal Function: Breastmilk and Fish are Good For You.
Ann. Rev. Cell. Dev. Biol (2005) |
Tong, W., J. Zhang, and H. F. Lodish.
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation
and downstream signaling pathways. Blood 105: 4604 - 4612 (2005). |
Lu, X., R. Levine, W. Tong, G. Wernig, Y. Pikman, S. Zarnegar, D. G. Gilliland and H. F. Lodish.
Expression of a Type I Cytokine Receptor is Required for JAK2V617F-mediated Transformation of Hematopoietic Cells. Proc. Natl. Acad. Sci. USA 102: 14605 ?14610 (2005) . |
Ruan, H. and H. F. Lodish.
Dyslipidemia and Atherosclerosis: mechanism, transcriptional
regulation, consequences, and treatment. Lipid Disorder
Updates in the press (2005) |
Zhao, W., C. Kitidis, M. D. Fleming, H. F. Lodish, and S. Ghaffari
Activated AKT Induces Erythroid Cell Maturation Through GATA-1-Dependent and Independent Mechanisms
Blood 107: 907 ?915 (2006). |
Ghaffari, S., C. Kitidis,
W. Zhao, D. Marinkovic, M. D. Fleming, B. Luo, J. Marszalek.,
and H. F. Lodish.
AKT
induces erythroid cell maturation of JAK2-deficient fetal
liver progenitor cells and is required for Epo regulation
of erythroid cell differentiation Blood 107: 1888 ?
1891 (2006) |
Gross, A., and H. F. Lodish.
Cellular
Trafficking and Degradation of Erythropoietin and NESP.
J Biol Chem. 2006 Jan 27;281(4):2024-32. Epub 2005 Nov 11
|
Zhang, C-C., A. D. Steele,
S. L. Lindquist, H. F. Lodish.
Prion protein is expressed on long-term repopulating hematopoietic
stem cells and is necessary for their self-renewal. .
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2184-9. Epub
2006 Feb 7.. |
Zhang, C-C,. M. Kaba, G. Ge,
K. Xie, W. Tong, C. Hug and H. F. Lodish.
Angiopoietin-like proteins stimulate ex vivo expansion of
hematopoietic stem cells. Nature Medicine 12, 240-245
(2006) |
Um, M, and H. F. Lodish.
Antiapoptotic effects of Erythropoietin in differentiated
neuroblastoma SH-SY5Y cells require activation of both STAT5
and AKT pathways.J. Biol. Chem. 281: 5648 - 5656. |
Lu, X., A. Gross, and H. F. Lodish.
Active Conformation of the Erythropoietin Receptor: Random
and Cysteine-Scanning Mutagenesis of the Extracellular, Juxtamembrane,
and Transmembrane Domains.J. Biol. Chem.281: 7002 - 7011. |
Hubbard, B., S. H. Doege, S. Punreddy, H. Wu, X. Huang,
V. Kaushik, R. L. Mozell, J. Byrnes, A. Stricker-Krongrad,
J. Chou, L. A. Tartaglia, H. F. Lodish, A. Stahl, and R. E.
Gimeno
Mice deleted for fatty acid transport protein 5 have defective
bile acid conjugation and are protected from obesity.
Gastroenterology. 2006 Apr;130(4):1259-69. |
Rao, P., R. Kumar, M. Farkhondeh, S. Baskerville, and H.
F. Lodish.
Myogenic factors that regulate expression of muscle
specific microRNAs. Proc. Natl. Acad. Sci. USA 103: 8721-
8726 (2006) |
Tong, W., R. Sulahian, A. W. Gross, N. Hendon, H. F. Lodish, and L. J-s Huang.
The membrane proximal region of the thrombopoietin receptor (TpoR) confers its high surface expression by JAK2- dependent and independent mechanisms.
J. Biol. Chem. 281:38930 - 38940 (2006) |
Wong, K., and H. F. Lodish.
A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits
J. Biol. Chem. 281: 36434 - 36442 (2006). |
Scott, L., W. Tong, R. L. Levine, M. A. Scott, P. A Beer, M. R. Stratton, P. A. Futreal, W. Eber, M. F. McMullin, C. N. Harrison, W. M. Erber, A. J. Warren, D. G. Gilliland, H. F. Lodish, A. R. Green.
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.
N. England J. Med. 356: 459 - 68 (2007). |
Um, M. A. Gross, and H. F. Lodish.
A homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y cells.
Cell Signaling 19: 634 -645 (2007) |
Tong, W., Ibarra, Y. M., and H. F. Lodish.
Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal.
Exp Hematol. 35(9):1447-55. (2007). |
Eshghi, S., M. G. Vogelezang, R. O. Hynes, L. G. Griffith, and H. F. Lodish.
Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development.
J Cell Biol.177(5):871-80. (2007). |
Zhou, B., S. Wang, C, Mayr, D.P. Bartel, and H. F. Lodish.
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.
Proc. Natl. Acad. Sci. USA 104: 7080 -7085 (2007) |
Shuga, J., J. Zhang, L. D. Samson, H. F. Lodish, and L. Griffith.
In vitro erythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds
Proc Natl Acad Sci U S A. 104(21):8737-42. (2007). |
Zhang, J., Y. Liu, C. Beard, D. A. Tuveson, R. Jaenisch, T. E. Jacks and H. F. Lodish.
Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways.
Blood. 109(12):5238-41. (2007). |
Liao, M.-J., C. Zhang, B. Zhou, M. Kaba, A. Gifford, F. Reinhardt, S. A. Mani, H. F. Lodish, and R. A. Weinberg.
Enrichment of a population of mammary gland cells that forms mammospheres and has in vivo repopulating activity.
Cancer Res. 67(17):8131-8. (2007). |
Zhang, J., and H. F. Lodish.
Endogenous K-ras signaling in erythroid differentiation.
Cell Cycle. 6(16):1970-3. (2007). |
Hattangadi, S., and H. F. Lodish.
Regulation of Erythrocyte Lifespan: Is the Clock Set by ROS?
J Clin Invest. (Commentary) 117(8):2075-7. (2007). |
Zhang, C-C,. M. Kaba, S. Iizuka, HD Huynh, and H. F. Lodish.
Angiopoietin-like protein 5 and IGFBP-2 stimulate ex vivo expansion of human hematopoietic stem cells.
Blood 111: 3415 - 3423 (2008) |
Huynh, HD., S. Iizuki, M. Kaba, O. Kirak, J. Zheng, H. F. Lodish, and C. C. Zhang.
IGFBP2 secreted by a tumorigenic cell line supports ex vivo expansion of hematopoietic stem cells.
Stem Cells. 26(6):1628-35 (2008) |
Wong, G.W., S. A. Krawczyk, C. Kitidis-Mitrokostas, T. Revett,
R. Gimeno, and H. F. Lodish.
Molecular, biochemical, and functional characterizations of C1q/TNF family members: adipose tissue-selective
expression patterns, regulation by PPAR-gamma agonist, Cys-mediated
oligomerizations, combinatorial associations, and metabolic
functions.
Biochem. J. 416(2):161-77 (2008). |
Lu, X., L. Huang, and H. F. Lodish
Dimerization by a cytokine receptor is necessary and sufficient for constitutive activation of JAK2V617F.
J. Biol. Chem 283: 5258 - 5266 (2008). |
Ji, Peng, S. Jayapal, and H. F. Lodish
Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2.
Nature Cell Biology 10: 314 - 321 (2008) |
Lodish, H.F., B. Zhou, G. Liu, and C.-Z. Chen.
Micromanaging the Immune System by microRNAs.
Nature Reviews in Immunology. 8: 120 - 130 (2008) |
Zhang, CC and H. F. Lodish.
Cytokine Regulation of Hematopoietic Stem Cell Function.
Current Opinion in Hematoogy. 15(4):307-11 (2008) |
Herrlich, A., E. Kleinman, J. Fu, C. Sadegh, and H. F. Lodish
Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes.
FASEB Journal. 22: 4281-4295 (2008). |
Lodish, H. F., A. Berk, C. Kaiser, M. Krieger, M. Scott, A. Bretscher, H. Ploegh, and P. Matsudaira.
Molecular Cell Biology, 6th ed. W. H.. Freeman and Company, N.Y. (2008). |
Lodish, H. F., S. Ghaffari, M. Socolovsky, W. Tong, and J. Zhang.
Intracellular Signaling by the Erythropoietin Receptor in Erythropoiesis and Eythropoietins (Second Edition) Editors: G Molineux, MA Foote, and SG Elliott. Birkhauser 155-174 (2009). |
Wong, G.W., S. A. Krawczyk, C. Kitidis-Mitrokostas, G. Ge, E. Spooner, C. Hug, R. Gimeno, and H. F. Lodish.
Identification and characterization of CTRP9, a novel secreted glycoprotein from adipose tissue that reduces serum glucose in mice and forms heterotrimers with Adiponectin.
FASEB J. 23(1):241-58(2009). |
Zhang, Y. L., M. L. Radhakrishnan, X. Lu, A. Gross, B. Tidor, and H. F. Lodish.
Symmetric Signaling by an Asymmetric 1 Erythropoietin: 2 Erythropoietin Receptor Complex.
Mol Cell. 33(2):266-74 (2009). |
Xie, H., B. Lim, and H. F. Lodish.
MicroRNAs Induced during Adipogenesis That Accelerate Fat Cell Development Are Downregulated in Obesity.
Diabetes. 58:1050-1057 (2009). |
Le, MT., C. The, S-S Ng, H. Xie, B. Zhou, V. Korzh, H. F. Lodish, and B. Lim.
MicroRNA-125b is a novel negative regulator of p53.
Genes and Development 23:862-876 (2009). |
Zhang, J., , J. Wang, Y. Liu, H. Sidik, K. Young, H. F. Lodish, and M. Fleming.
Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the targets for final leukemic transformation.
Blood 113:1304-1314 (2009). |
Wood, A.. D., E. Chen, I. Donaldson, S. Hattangadi, K. Burke, D. Miranda-Saavedra, H. F. Lodish, A. R. Green, and B. Gottgens.
Id1 promotes expansion and survival of primary erythroid cells and is a direct target of JAK2V617F-STAT5 signalling.
Blood. 114(9):1820-30 (2009). |
Le, MT, H. Xie, B. Zhou, P. Chia, M. Um, G.Udolph, H.Yang, B. Lim and H. Lodish.
microRNA-125b Promotes Neuronal Differentiation in Human Cells by Repressing Multiple Targets.
Mol Cell Biol. in the press (2009). |
Xie, H., Sun, L. and H.F. Lodish.
Targeting microRNAs in obesity.
Expert Opin Ther Targets. in the press (2009). |
Rao, P., Y. Toyama, R. Chiang, S. Gupta, M. Bauer, R. Medvid, F. Reinhardt, R. Liao, M. Krieger, R. Jaenisch, H. F. Lodish, and R. Blelloch.
Loss of cardiac microRNA regulation leads to dilated cardiomyopathy and heart failure.
Circ Res. in the press (2009). |
Kotani, A., D. Ha, J. Hsieh, P. Rao, D. Schotte, M. den Boer, S. Armstrong, and H. F. Lodish.
miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 Acute Lymphocytic Leukemia cells and exerts cooperative effects with miR-221.
Blood. in the press (2009). |
Duraisingh, M. and H. F. Lodish.
Sickle cell microRNAs inhibit the malaria parasite.
Cell Host and Microbe. in the press (2009). |
Ji, P. and H. F. Lodish.
Rac GTPases play multiple roles in erythropoiesis.
Haematologica. in the press (2009). |
Sieff, C., L. B. Merida-Long, J. Yang, and H. F. Lodish.
Pathogenesis of the Erythroid Failure in Diamond Blackfan Anemia.
British J of Haematology. Submitted (2009). |
Flygare, J., and H. F. Lodish.
Glucocorticoids stimulate self-renewal of BFU-Es, increase production of CFU-E erythroid progenitors, and enhance terminal erythroid differentiation.
Blood. Submitted (2009). |
Hattangadi, S., K. Burke, and H.F. Lodish.
Homeodomain-interacting protein kinase 2 is essential for terminal fetal liver erythroid proliferation and differentiation.
Blood. Submitted (2009). |
Ramirez, T., P. Ji, S. Jayapal, H. F. Lodish and M. Murata-Hori.
Mammalian erythroblast enucleation is achieved by a novel mechanism different from that of cytokinesis.
Nature. Submitted (2009). |
Sieff CA, Yang J, Merida-Long LB, Lodish HF.
Pathogenesis of the erythroid failure in Diamond Blackfan anaemia. (Br J Haematol. 2010 Feb;148(4):611-22. Epub 2009 Dec 1. (2010). |
Zhang J, Lee EY, Liu Y, Berman SD, Lodish HF, Lees JA.
pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis.
Cell Cycle. 2010 |
Ji P, Lodish HF.
Rac GTPases play multiple roles in erythropoiesis.
Haematologica. 2010 |
Hattangadi SM, Burke KA, Lodish HF.
Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation.
Blood. 2010 |
Kotani A, Ha D, Schotte D, den Boer ML, Armstrong SA, Lodish HF.
A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells.
Cell Cycle. 2010 |
Chou S, Lodish HF.
Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells.
Proc Natl Acad Sci U S A. 2010 |
Rao PK, Missiaglia E, Shields L, Hyde G, Yuan B, Shepherd CJ, Shipley J, Lodish HF.
Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells.
PFASEB J. 2010 |
Sun Y, Lodish HF.
Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration.
PLoS One. 2010 |
Ji P, Yeh V, Ramirez T, Murata-Hori M, Lodish HF.
Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts.
Haematologica. 2010 |
Jayapal SR, Lee KL, Ji P, Kaldis P, Lim B, Lodish HF.
Down-regulation of Myc is essential for terminal erythroid maturation.
J Biol Chem. 2010 |
Bousquet M, Harris MH, Zhou B, Lodish HF.
MicroRNA miR-125b causes leukemia.
Proc Natl Acad Sci U S A. 2010 |
|
Khoury M, Drake A, Chen Q, Dong D, Leskov I, Fragoso MF, Li Y, Iliopoulou BP, Hwang W, Lodish HF, Chen J
Mesenchymal Stem Cells Secreting Angiopoietin-Like-5 Support Efficient Expansion of Human Hematopoietic Stem Cells Without Compromising Their Repopulating Potential.
Stem Cells Dev. 2011 |
Flygare J, Rayon Estrada V, Shin C, Gupta S, Lodish HF.
HIF-1 {alpha} synergizes with glucocorticoids to promote BFU-E progenitor self-renewal.
Blood. 2011 |
` Zhang L, Flygare J, Wong P, Lim B, Lodish HF.
miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.
Genes Dev. 2011 |
` Sankaran VG, Menne TF, Scepanovic D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF.
MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.
Proc Natl Acad Sci U S A. 2011 |
Bousquet M, Lodish HF.
MicroRNAs: the primary cause or a determinant of progression in leukemia?
Expert Rev Hematol. 2011 |
Ji P, Murata-Hori M, Lodish HF.
Formation of mammalian erythrocytes: chromatin condensation and enucleation.
Trends Cell Biol. 2011 |
Sun L, Xie H, Mori MA, Alexander R, Yuan B, Hattangadi SM, Liu Q, Kahn CR, Lodish HF.
Mir193b-365 is essential for brown fat differentiation.
Nat Cell Biol. 2011 |
Drake, A., M. Khoury, I. Leskov, B. Iliopoulou, M. Fragoso, H. Lodish, and J. Chen Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rgamma-/- (NSG) mice. PLoS ONE; 6: e18382.
Dang, M., K. Dubbin, A. D’Aiello, M. Stopinska, H. Lodish, and A. Herrlich EGF-ligand cleavage is regulated on the substrate level in a cell- specific manner. J. Biol. Chem. 286:17704-13 (2011).
Hattangadi, S., P. Wong, L. Zhang, J. Flygare, and H. Lodish From stem cell to red cell: Regulation of erythropoiesis at multiple levels by multiple proteins, RNAs and chromatin modifications. Blood 118: 6258 - 6268 (2011).
Alexander, R., H. Lodish, and L. Sun MicroRNAs as therapeutic targets for mitigating obesity. Expert Opinion on Therapeutic Targets 15: 623 - 636 (2011)
|
Le, M. T. N., N. Shyh-Chang, S. L. Khaw, M. Chin, C. Teh, J. Tay, E. O’Day, V. Korzh, H. Yang, A. Lal, J. Lieberman, H. Lodish, and B. Lim Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs PLOS Genetics 7: e1002242 (2011)
|
Bousquet, M. and H. Lodish. MicroRNAs: the primary cause or a determinant of progression in leukemia? Expert Review of Hematology 4: 121 - 123 (2011)
|
Wong, P., S. Hattangadi, A. Cheng, G. Frampton, R. A. Young, and H. Lodish. Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood 118: e128 – e138 (2011).
|
Ji, P., M. Murata-Hori, and H. Lodish, Formation of mammalian erythrocytes: Chromatin condensation and enucleation. Trends in Cell Biology 21: 409-415 (2011).
|
Hu, W., B. Yuan, J. Flygare, and H. Lodish Long non-coding RNA- mediated antiapoptotic activity in murine erythroid terminal differentiation. Genes and Development 25: 2573- 2578 (2011).
|
Ji, P. and H. Lodish Ankyrin and Band 3 Differentially Affect Expression of Membrane Glycoproteins But Are Not required for Erythroblast Enucleation Biochem Biophys Res Comm 417: 1188 – 1192 (2012). |
Wang, J., T. Ramirez, P. Ji, S. Jayapal, H. F. Lodish and M. Murata-Hori. Mammalian erythroblast enucleation requires PI(3)K-dependent cell polarization. J. Cell. Science. 125: 340 - 349 (2012) |
`
Zhang, L., Sankaran, V. and H. Lodish MicroRNAs in normal myeloerythropoiesis. Leukemia in the press (2012) |
`
Sun, L., C. Trapnell, L. Goff, R. Alexander, A. Lo, M. Kellis, H. Lodish, and J. Rinn. Long noncoding RNAs regulate adipogenesis. Developmental Cell submitted (2012) |
Chou, S., J. Flygare, and H. Lodish. Fetal Hepatic Progenitors Support Long-term Expansion of Hematopoietic Stem Cells. Blood submitted. (2012) |
Zhang, L., Sankaran, V. and H. Lodish. MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Leukemia 26: 2310-2316. (2012). |
Sankaran, V., L. S. Ludwig, E. Sicinska, J. Xu, D. E. Bauer, J. C. Eng, H. C. Patterson, R. A. Metcalf, Y. Natkunam, S. H. Orkin, P. Sicinski, E. S. Lander, and H. F. Lodish. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes and Development 26: 2075-2087. (2012) |
Bousquet, M., D. Nguyen, C. Chen, L. Shields, and H. Lodish. miR-125b transforms myeloid progenitors by repressing multiple mRNA targets. Haematologica 97: 1713-1721. (2012). |
Liu, Q, B. Yuan, K. Lo, H. Patterson, Y. Sun, and H. Lodish. Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism. PNAS 109: 14568 - 14573. (2012). |
Hu, W., J. Alvarez-Dominguez, and H. Lodish. Regulation of Mammalian Cell Differentiation by Long Noncoding RNAs. EMBO Reports 13: 971 - 983. (2012). |
Duraisingh, M. and H. Lodish. Sickle cell microRNAs inhibit the malaria parasite. Cell Host and Microbe 12: 127-128. (2012). |
Lodish, H. Reflections, Translational Control of Protein Synthesis: The Early Years. J. Biol. Chem. 287: 36528 - 36535. (2012). |
Lodish, H. F., and N. Fedoroff. Retrospective: Norton Zinder (1928-2012) Science 335:6074 (2012)
Lodish, H. F., A. Berk, C. Kaiser, M. Krieger, A. Bretscher, H. Ploegh, A. Amon, and M. Scott, Matsudaira. Molecular Cell Biology, 7th ed. W. H.. Freeman and Company, N.Y. (2012).
|
Alvarez-Dominguez, J., W. Hu, and H. Lodish. Regulation of Eukaryotic Cell Differentiation by Long Noncoding RNAs. The Molecular Biology of Long Non-coding RNAs. J. Coller and A. Khalil, eds., Springer Science, in the press. (2013). |
Chen, C., D. Garcia-Santos, Y. Ishikawa, A. Seguin, L. Li, K. Fegan, G. Hildick-Smith, D. Shah, J. D. Cooney, W. Chen, M. King, Y. Yien, I. Schultz, H. Anderson, A. Dalton, M. Freedman, P. Kingsley, J. Palis, S. Hattangadi, H. Lodish, D. Ward, J. Kaplan, T. Maeda, P. Ponka, and B. Paw. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metabolism 17:343 - 352. (2013). |
`
Lo, K., A. Labadorf, .L Sun, N. Kennedy, R. Davis, H. Lodish, and E. Fraenkel. Comprehensive analysis of four in vitro insulin resistance models and their physiological relevance to adipose insulin resistance resulting from diet-induced obesity. Cell Reports in the press. (2013). |
`
Okuyama, K., T. Ikawa, R. Harnprasopwat, J. Lu, R. Yamashita, D. Ha, T. Toyoshima, B. Chanda, T. Kawamata, K. Yokoyama, B. Gertner, S. Wang, K. Ando, H. Lodish, A. Tojo, H. Kawamoto, and A. Kotani. miR-126-mediated control of cell fate in B cell-myeloid progenitors as a potential alternative to transcriptional factors. PNAS in the press. (2013). |
Sun, L., L. Goff, C. Trapnell, R. Alexander, A. Lo, E. Hacisuleyman, M. Savageau, B. Tazon-Vega, D. Kelley, D. Hendrickson, B. Yuan, M. Kellis, H. Lodish, and J. Rinn. Long noncoding RNAs regulate adipogenesis. PNAS 110:3387 - 3392. (2013). |
Chou, S., J. Flygare, and H. Lodish. Fetal Hepatic Progenitors Support Long-term Expansion of Hematopoietic Stem Cells. Experimental Hematology 41: 479-490. (2013). |
Zhang, L., L. Prak, J. Flygare, V. R. Estrada, P. Thiru, B. Lim, and H. F. Lodish. Zfp36l2 is required for self-renewal of early erythroid BFU-E progenitors. Nature 499, 92-96. (2013). |
Dang, M., N. Armbruster, M. Miller, E. Cermeno-Blondet, M. Hartmann, G. Bell, D. Root, D. Lauffenburger, H. Lodish, and A. Herrlich. Regulated ADAM17 dependent EGF family ligand release through separate and distinct signaling pathways without increase of protease activity. PNAS 110: 9776 - 9781. (2013). |
Trajkovski, M. and Lodish, H. MicroRNA networks regulate development of brown adipocytes. Trends Endocrinology and Metabolism in the press. (2013). |
Shi, J.,B. Yuan, W. Hu, and H. Lodish. JAK2-V617F enhances red cell production by triggering CFU-E self-renewal. J. Clin. Invest. submitted (2013). |
Chen, C., and H. Lodish. E2F binding partner TFDP2 regulates terminal erythroid differentiation by modulating cell cycle progression. Blood submitted (2013). |
Pishesha, N., P. Thiru, J. Shi, J. Eng, V. Sankaran, and H. Lodish. Transcriptional divergence and conservation of human and mouse erythropoiesis. Blood submitted (2013). |
Alvarez-Dominguez JR, Hu W, Yuan B, Shi J, Park SS, Gromatzky AA, van Oudenaarden A, Lodish HF. Global discovery of erythroid long non-coding RNAs reveals novel regulators of red cell maturation. Blood 2013 Nov 7. |
|