Group Photos


How to Reach Us

Contact Info

Lab directory



Search PubMed for Lodish lab articles

1994 | 1995 | 1996 | 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013



Back to top


Longmore, G.D., P.N. Pharr, and H.F. Lodish. A constitutively erythropoietin receptor stimulates proliferation and induces transformation of multipotent, committed nonerythroid and erythroid progenitor cells. Molecular & Cell. Biol. 14: 2266-2277 (1994).

Watowich, S. S., D. J. Hilton, H. F. Lodish. Activation and inhibition of erythropoietin receptor function: Role of receptor dimerization. Mol. & Cell. Biol. 14: 3535-3549 (1994).

Bhushan, A., H.Y. Lin, H.F. Lodish and C.R. Kintner. The transforming growth factor beta type II receptor can replace the activin type II receptor in inducing mesoderm. Mol. & Cell. Biol. 14: 4280-4285 (1994).

Henis, Y. I., A. Moustakas, H. Y. Lin, and H. F. Lodish. The Type II and Type III transforming growth factor-beta receptors form homo-oligomers. J. Cell Biol. 126: 139-154 (1994) .

Acton, S. L., P. E. Scherer, H. F. Lodish and M. Krieger. Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J. Biol. Chem. 269: 21003-21009 (1994).

Schaffer, J. and H. F. Lodish. Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 79: 427-436 (1994).

Chun, M., U. K. Liyanage, M. P. Lisanti, and H. F. Lodish. Signal transduction of a G-protein coupled receptor in caveolae: Colocalization of endothelin and its receptor with caveolin. Proc. Natl. Acad. Sci. USA. 91: 11728-11732 (1994).

Takumi, T. and H. F. Lodish. Rapid cDNA cloning by PCR screening (RC-PCR). BioTechniques 17: 443-444 (1994).

Scherer, P. E., M. P. Lisanti, G. Baldini, M. Sargiacomo, C. C. Mastick, and H. F. Lodish. Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles. J. Cell Biol. 127: 1233-1243 (1994).

Efrat, S., M. Tal, and H. F. Lodish. The pancreatic beta-cell glucose sensor. Trends in Biochemical Sciences 19: 535-538 (1994).

Simonsen, H. and H. F. Lodish. Cloning by function: expression cloning in mammalian cells. Trends in Pharmacological Sciences 15: 437-441 (1994).



Back to top

Hilton, D. J., S. S. Watowich, P. J. Murray, and H. F. Lodish. Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor. Proc. Natl. Acad. Sci. USA. 92: 190-194 (1995).

Moustakas, A., T. Takumi, H. Y. Lin, and H. F. Lodish. GH3 Pituitary tumor cells contain heteromeric type I and type II receptor complexes for transforming growth factor beta and activin A. J. Biol. Chem. 270: 765-769 (1995).

Takumi, T., A. Moustakas, H. Y. Lin, and H. F. Lodish. Molecular characterization of a type I serine-threonine kinase receptor for TGF-beta and activin in the rat pituitary tumor cell line CH3. Experimental Cell Research.216: 208-214 (1995).

Lin, H. Y., A. Moustakas, P. Knaus, R. G. Wells, Y. I. Henis, and H. F. Lodish. The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. J. Biol. Chem. 270: 2747-2754 (1995).

Klingmueller, U., U. Lorenz, L. C. Cantley, B. G. Neel, and H. F. Lodish. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell. 80: 729-738 (1995).

Lodish, H. F., D. Baltimore, A. Berk, L. Zipursky, P. Matsudaira, and J. E. Darnell. Molecular Cell Biology, 3rd ed. Scientific American Press, N.Y. (1995).

Baldini, G., P. E. Scherer, and H. F. Lodish. Nonneuronal expression of Rab3A: Induction during adipogenesis and association with different intracellular membranes than Rab3D. Proc. Natl. Acad. Sci. USA. 92: 4284-4288 (1995).

Chun, M., H. Y. Lin, Y. I. Henis, and H. F. Lodish. Endothelin-induced endocytosis of cell surface ETA receptors: Endothelin remains intact and bound to the ETA receptor. J. Biol. Chem. 270: 10855-10860 (1995).

Scherer, P. E., Z. Tang, M. Chun, M. Sargiacomo, H. F. Lodish, and M. P. Lisanti. Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution: Identification and epitope mapping of an isoform-specific monoclonal antibody probe. J. Biol. Chem. 270: 16395-16401 (1995).

Rodriguez, C., F. Chen, R. Weinberg, and H. F. Lodish. Cooperative binding of TGF-beta2 to the types I and II TGF-beta receptors. J. Biol. Chem.: 270 15919-15922 (1995).

Yuk, M. H. and H. F. Lodish. Enhanced folding and processing of a disulfide mutant of the human asialoglycoprotein receptor H2b subunit. J. Biol. Chem.270 20169-20176 (1995).

Murray, P. J., S. S. Watowich, H. F. Lodish, R. A. Young, and D. J. Hilton. Epitope tagging of the human endoplasmic reticulum HSP70 protein, BiP, to facilitate analysis of BiP-substrate interactions. Anal. Biochem. 229: 170-179 (1995)

Wu, H., U. Klingmueller, and H. F. Lodish. Physical and functional interaction of the erythropoietin and stem cell factor receptors. Nature 377: 242-246 (1995).

Wu, H., X. Liu, R. Jaenisch, and H. F. Lodish. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or erythropoietin receptor. Cell 83: 59-67 (1995).

Martelli, A. M., R. Bareggi, G. Baldini, P. E. Scherer, H. F. Lodish, and G. Baldini. Diffuse vesicular distribution of Rab3D in the polarized neuroendocrine cell line AtT-20. FEBS Letters 368: 271-275 (1995).

Chen, K., G. N. Stephanopoulos, A. J. Sinskey, and H. F. Lodish. Regulated secretion of prolactin by the mouse insulinoma cell line betaTC-3. BioTechnology 13; 1191-1197 (1995)

Hwang, C., H. F. Lodish, and A. J. Sinskey. Measurement of glutathione redox state in cytosol and secretory pathway of cultured cells. Methods in Enzymology 251: 212-221 (1995).

Scherer, P. E., S. Williams, M. Fogliano, G. Baldini, and H. F. Lodish. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270: 26746-26749 (1995).

Schaffer, J. E. and H. F. Lodish. Molecular mechanism of long chain fatty acid uptake. Trends in Cardiovascular Medicine 5: 218-224 (1995).

Luo, K., P. Zhou, and H. F. Lodish. The specificity of the transforming growth factor beta receptor kinases determined by a spatially addressable peptide library. Proc. Natl. Acad. Sci. USA. 92: 11761-11765. (1995)



Back to top

Tang, Z.L., P. E. Scherer, T. Okamoto, K. Song, C. Chu, D. S. Kohtz, I. Nishimoto, H. F. Lodish, and M. P. Lisanti. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. J. Biol. Chem.271: 2255-2261 (1996).

Scherer, P. E., T. Okamoto, M. Chun, I. Nishimoto, H. F. Lodish, and M. P. Lisanti. Identification, sequence and expression of caveolin-2 defines a caveolin gene family. Proc. Natl. Acad. Sci. USA. 93: 131-135. (1996).

Hilton, D. J., S. S. Watowich, L. Katz, and H. F. Lodish Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor. J. Biol. Chem. 271: 4699-4708 (1996).

Cohen, N. R., D. A. Knecht, and H. F. Lodish. Functional expression of rat glut 1 glucose transporter in Dictyostelium discoideum. Biochemical J. 315: 971-975 (1996).

Neumann, D., H. F. Lodish, M. H. Yuk, and G. Z. Lederkremer. Blocking intracellular degradation of the erythropoietin and asialoglycoprotein receptors by calpain inhibitors does not result in the same increase in the levels of their membrane and secreted forms. Biochemical J. 313: 391-399 (1996).

Scherer, P. E., G. Z. Lederkremer, S. Williams, M. Fogliano, G. Baldini, and H. F. Lodish. Cab45, a novel Ca2+-binding protein localized to the Golgi lumen. J. Cell Biology 133: 257-268 (1996).

Lodish, H. F., D. J. Hilton, U. Klingmueller, S. Watowich, and H. Wu. The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction. Cold Spring Harbor Symposium. Vol 60: 93-104.(1996)

Tolchinsky, S., M. H. Yuk, M. Ayalon, H. F. Lodish, and G. Z. Lederkremer. Membrane-bound versus secreted forms of human asialoglycoprotein receptor subunits. J. Biol. Chem. 271: 14496-14503 (1996).

Knaus, P. I., D. Lindemann, J. F. DeCoteau, R. Perlman, H. Yankelev, M. Brooks, M. Hille, M. E. Kadin, and H. F. Lodish. A dominant inhibitory mutant of the type II TGF-beta receptor in the malignant progression of a cutaneous T-cell lymphoma. Mol. Cell Biol. 16: 3480-3489 (1996).

Mann, M. Z., T. Y. Hui, J. E. Schaffer, H. F. Lodish, and D. A. Bernlohr. Regulation of the murine adipocyte fatty acid transporter gene by insulin. Molecular Endocrinology 10: 1021-1028 (1996).

Klingmueller, U., S. Bergelson, J. G. Hsiao, and H. F. Lodish. Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5. Proc. Nat. Acad. Sci. USA. 93: 8324-8328 (1996).

Luo, K. and H. F. Lodish Signaling by chimeric erythropoietin-TGF-beta Receptors: Dimerization of the type I TGF-beta receptor cytoplasmic domain is required for intracellular signal transduction. EMBO Journal 15: 4485-4496 (1996).

Watowich, S. S., H. Wu, M. Socolovsky, U. Klingmueller, S. Constantinescu, and H. F. Lodish. Cytokine receptor signal transduction and the control of hematopoietic cell development. Ann. Rev. Cell. Biol. 12: 91-128 (1996).



Back to top

Wu, H., U. Klingmueller, A. Acurio, J. G. Hsiao, and Lodish, H. F. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc. Natl. Acad. Sci. USA 94: 1806-1810 (1997).

Klingmueller, U., H. Wu, J. G. Hsiao, A. Toker, B. C. Duckworth, L. C. Cantley, and H. F. Lodish. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc. Natl. Acad. Sci. USA 94: 3016-3021 (1997).

Wells, R. G., H. Yankelev, H. Lin, and H. F. Lodish Biosynthesis of the type I and type II TGF-beta receptors: Implications for complex formtion. J. Biol. Chem. 272: 11444-11451 (1997).

Bickel, P., P. E. Scherer, J. E. Schnitzer, P. Oh, M. P. Lisanti, and H. F. Lodish. Flotillin and ESA define a new family of caveolae-associated integral membrane proteins. J. Biol. Chem. 272: 13793-13802 (1997).

Socolovsky, M., I. Dusanter-Fourt, and H. F. Lodish. The prolactin receptor and severely truncated erythropoietin receptors support differentiation of committed erythroid progenitors. J. Biol. Chem. 272: 14009-14012 (1997).

Luo, K. and H. F. Lodish. Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues. EMBO Journal 16: 1970-1981 (1997).

DeCoteau, J. F., P. I. Knaus, H. Yankelev, M. D. Reis, R. Lowsky, H. F. Lodish, and M. E. Kadin. Loss of functional cell surface Transforming Growth Factor beta (TGF-beta) type I receptor correlates with insensitivity to TGF-beta in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 94: 5877-5881 (1997).

Liu, X., Y. Sun, S. N. Constantinescu, E. Karam, R. A. Weinberg, and H. F. Lodish. TGF-beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl. Acad. Sci. USA 94: 10669-10674 (1997).



Back to top

Bergelson, S., U. Klingmueller, M. Socolovsky, J. Hsiao, and H. F. Lodish. Tyrosine residues within the intracellular domain of the erythropoietin receptor mediate activation of AP-1 transcription factors. J. Biol. Chem. 273: 2396-2401 (1998)

Brink, R. and H. F. Lodish. Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kB activation. J. Biol. Chem. 273: 4129-4134 (1998).

Constantinescu, S., H. Wu, X. Liu, W. Beyer, A. Fallon, and H. F. Lodish. The Anemic Friend Virus gp55 envelope protein induces erythroid differentiation in fetal liver CFU-Es. Blood 91: 1163-1172 (1998).

Gilboa, L., R. G. Wells, H. F. Lodish, and Y. I. Henis. Oligomeric Structure of Type I and Type II TGF-beta Receptors: Homo-dimers form at the ER and persist at the plasma membrane. J. Cell Biol. 140: 767-777 (1998)

Rodriguez, C. and H. F. Lodish. Enhanced efficiency of cloning FACS-sorted mammalian cells. Biotechniques 24: 750-752 (1998)

Socolovsky, M., H. F. Lodish, and G. Q. Daley. Control of hematopoietic differentiation: Lack of specificity in signaling by cytokine receptors. Proc. Natl. Acad. Sci. USA. 95: 6573-6575 (1998)

Scherer, P. E., P. E. Bickel, M. Kotler, and H. F. Lodish. Cloning of cell-specific and surface proteins by subtractive antibody screening. Nature Biotechnology 16: 581-586.

Hirsch, D. J., A. Stahl, and H. F. Lodish. A family of fatty acid transporters conserved from mycobacterium to man. Proc. Natl. Acad. Sci. USA 95: 8625-8629 (1998).

Socolovsky, M., A. Fallon, and H. F. Lodish. The prolactin receptor rescues Epo-R-/-Erythroid progenitors and replaces EpoR in a synergistic interaction with c-kit. Blood. 92: 1491-1496 (1998).

Socolovsky, M.,  S. N. Constantinescu, S. Bergelson, A. Sirotkin, and H. F. Lodish. Cytokines in Hematopoiesis: Specificity and Redundancy in Receptor Function. In Advances in Protein Chemistry, J. Wells, ed. 52: 142-199. (1998)

Hua, Xianxin, X. Liu, D.O. Ansari, and H.F. Lodish. Synergistic cooperation of TFE3 and Smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor- 1 gene. Genes and Development. 12: 3084-3095 (1998).

Lin, R. S., C. Rodriguez, A. Veillette, and H. F. Lodish. Zinc is essential for binding of p56lck to CD4 and CD8alpha. J. Biol. Chemistry 273: 32878-32882 (1998)



Back to top

S. N. Constantinescu, S. Ghaffari and H. F.Lodish. Erythropoietin receptor: Structure, activation, and intracellular signal transduction. Trends in Endocrinology and Metabolism 10: 18-23 (1999).

Wells, R.G., L. Gilboa, Y. Sun, X. Liu, and H.F. Lodish. TGF-beta induces formation of a DTT-resistant type I / type II receptor complex in live cells.  J. Biol. Chemistry. 274: 5716- 5722 (1999).

Bogan, J. S., and H. F. Lodish. Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous GLUT4 and ACRP30. J. Cell Biol., 146: 609 - 620 (1999)

Constantinescu, S. N., X. Liu, W. Beyer, A. Fallon, S. Shekar, S. O. Smith, and H. F. Lodish. Activation of the murine erythropoietin receptor by a viral envelope protein involves specific interactions within transmembrane domains. EMBO J, 18: 3334- 3358 (1999).

Chatterton, J. E., D. Hirsch, J. J. Schwartz, P. E. Bickel, R. D. Rosenberg, H. F. Lodish and M. Krieger. Expression Cloning of LDLB, a Gene Essential for Normal Golgi Function and Assembly of a Novel Protein Complex. Proc. Natl. Acad. Sci. USA 96: 915 - 920 (1999).

Ghaffari, Saghi, G. Q. Daley, and H. F. Lodish. Growth factor independence and BCR/ABL transformation: Promise and pitfalls of available assays. Leukemia. Invited review Leukemia, 13: 1200- 1206 (1999).

Socolovsky, M., A. E. J. Fallon, S. Wang, C. Brugnara, and H. F. Lodish. Fetal anemia and apoptosis of red-cell progenitors in Stat5a-/-Stat5b-/- mice: a direct role for Stat5 in bcl-x - induction. Cell. 98: 181- 192 (1999).

Schiemann, W. P., W. M. Pfeifer, M. E. Kadin, and H. F. Lodish. A deletion in the gene for the transforming growth factor b type I receptor that abolishes its expression in a new human cutaneous T-cell lymphoma cell line. Blood, 94: 2854 - 2861 (1999).

Sun, Y., X. Liu, E. Ng Eaton, W. S. Lane, H. F. Lodish, and R. A. Weinberg. Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-b Signaling. Molecular Cell, 4: 499 &endash; 508 (1999).

Hua, X., Z. Miller, G. Wu, Y. Shi, and H. F. Lodish. Specificity in TGF-beta-Induced Transcription of the Plasminogen Activator Inhibitor-1 Gene: Interactions of Promoter DNA, Smad3, and TFE3. Proc. Natl. Acad. Sci. USA, 96: 13130 - 13135 (1999).

Stahl, A., D. J. Hirsch, R. Gimeno, S. Punreddy, P. Ge, N. Watson, S. Patel, M. Kotler, A. Raimondi, L. A. Tartaglia, and H. F. Lodish. Identification of the major intestinal fatty acid transport protein. Molecular Cell, 4: 299 - 308 (1999).

Sun, Y., X. Liu, E. Ng Eaton, H. F. Lodish, and R. A. Weinberg. SnoN and Ski Protooncoproteins are rapidly degraded in response to TGF-b signalling. Proc. Natl. Acad. Sci. USA, 96: 12442 - 12447 (1999).

Lodish, H. F., A. Berk, L. Zipursky, P. Matsudaira, D. Baltimore, and J. E. Darnell. Molecular Cell Biology, 4th ed. Scientific American Press, N.Y. (1999).

Ghaffari, S. H. Wu, K. M. Gerlach, Y. Han, H. F. Lodish, and G. Q. Daley. BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells. Proc. Natl. Acad. Sci. USA 96: 13186 - 13190 (1999).



Back to top

Pandey, A., A. V. Podtelejnikov, B. Blagoev, X. R. Bustelo, M. Mann, and H. F. Lodish. Analysis of receptor signaling pathways by mass spectrometry: Identification of Vav-2 as a novel substrate of the epidermal and platelet-derived growth factor receptors. Proc. Natl. Acad. Sci. USA 97: 179 - 184 (2000).

Brooks, C., P. Scherer, K. Cleveland, J. Whittemore, H. F. Lodish, and B. Cheatham. Pantophysin is a phosphoprotein component of adipocyte transport vesicles and associates with GLUT4- containing vesicles. J. Biol. Chem. 275: 2029 - 2036 (2000)

Liu, X., S. Constantinescu,, Y. Sun, J. S. Bogan, D. Hirsch, R. A. Weinberg,, and H. F. Lodish. Generation of mammalian cells stably expressing multiple genes at predetermined levels. Anal. Biochem. 280: 20-28 (2000).

Blobe, G.C., W. P. Schiemann, and H. F. Lodish. Role of Transforming Growth Factor ?in human disease. New Engl. Jour. Med. 342: 1350-1359 (2000).

Xiao, Z., X. Liu, Y. Henis, and H. F. Lodish. A distinct nuclear localization signal in the MH1 domain of Smad3 determines its ligand-induced nuclear translocation. Proc. Natl. Acad. Sci. USA 97: 7853 - 7858 (2000).

Xiao, Z., X. Liu, and H. F. Lodish. Importin beta Mediates Nuclear Translocation of Smad 3. J. Biol. Chem. 275: 23425 - 23428 (2000)

Pandey, A., K. Ozaki, H. Baumann, S. D. Levin, A. G. Farr, S. F. Ziegler, W. J. Leonard, and H. F. Lodish. Cloning of a novel receptor subunit required for signaling by Thymic Stromal Lymphopoietin. Nature Immunology 1: 59-64 (2000).

Yamamura, Y., X. Hua, S. Bergelson, and H. F. Lodish. Critical Role of Smads and AP-1 Complex in TGF-?Dependent Apoptosis. J. Biol. Chem. 275: 36295 - 36302 (2000)

Hua, X., Z. Miller, H. Benchabane, J. Wrana, and H. F. Lodish. Synergism between transcription factors TFE3 and Smad 3 in TGF-?induced transcription of the Smad 7 gene. J. Biol. Chem. 275: 33205 - 33208 (2000)

Chi, N-W and H. F. Lodish Tankyrase is a Golgi-associated MAP Kinase substrate that interacts with IRAP in GLUT4 vesicles J. Biol. Chem. 275: 38437 - 38444 (2000)

Pandey, A., M. Fernandez, H. Steen, B. Blagoev, M. Nielsen, S. Roche, M. Mann, and H. F. Lodish. Identification of an immunoreceptor tyrosine-based activation motif (ITAM) - containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. J. Biol. Chem. 275: 38633 - 38639 (2000)

Liu, X., Y. Sun, M. Ehrlich, T. Lu, Y. Kloog, R. A. Weinberg, H. F. Lodish, and Y. I. Henis. Disruption of TGF-?Growth Inhibition by Oncogenic Ras is Linked to p27Kip1 Mislocalization Oncogene 19: 5926 - 5935 (2000)

Bickel, P., H. F. Lodish, and P. Scherer. Use and Applications of Subtractive Antibody Screening. Biotechnology and Genetic Engineering Reviews. Vol. 17, Steven Harding, ed. pp 417 - 430 (2000).



Back to top

Constantinescu, S., L. Huang, H-S Nam, and H. F. Lodish. The Erythropoietin Receptor Cytosolic Juxtamembrane Domain Contains an Essential, Precisely Oriented, Hydrophobic Motif. Mol. Cell 7: 377 - 385 (2001)

Liu, X., Y. Sun, R. A. Weinberg and H. F. Lodish. Ski/Sno and TGF-?Signaling Cytokine and Growth Factor Reviews 12: 1- 8 (2001)

Fruebis, J., Tsao, T-S., Erickson, M. R., Lee, L., Yen, F., Bihain, B. E., and Lodish, H. F. A Proteolytic Cleavage Product of ACRP30 Increases Fatty Acid Oxidation in Muscle and Causes Weight Loss in Mice. Proc. Natl. Acad. Sci. USA 98: 2005 - 2010; (2001)

Constantinescu, S. N., T. Keren, M. Socolovsky, H-s Nam, Y. I. Henis and H. F. Lodish Ligand-Independent Oligomerization of Cell-Surface Erythropoietin Receptor Is Mediated by the Transmembrane Domain Proc. Natl. Acad. Sci. USA 98: 4379 - 4384 (2001)

Perlman, R., W. P. Schiemann, M. W. Brooks, H. F. Lodish and R. A. Weinberg. TGF-?induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation Nature Cell Biology 3: 708 - 714 (2001).

Bogan, J. B., A. E. McKee, and H. F. Lodish. Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrations. Mol. Cell Biol. 21: 4785 – 4806 (2001)

Blobe, G. C.,W. P. Scheimann, M.-C. Pepin, M. Beauchemin, A. Moustakas, H. F. Lodish. and M. D. O’Connor-McCourt. Functional Roles for the Cytoplasmic Domain of the Type III TGF-?Receptor in Transforming Growth Factor ?Signaling J. Biol. Chem. 276: 24627 - 24637 (2001)

Stahl, A., R. E. Gimeno, L. A. Tartaglia, and H. F. Lodish. Fatty acid transport proteins: A current view of a growing family. Trends in Endocrinology and Metabolism 12: 266 – 273 (2001)

Rodriguez, C., J.-S. L. Huang, J. K. Son, A. McKee, Z. Xiao and H. F. Lodish. Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of TGF-?signaling. J. Biol. Chem. 276: 30224 - 30230 (2001)

Xiao, Z., Watson, N., Rodriguez, C., and H. F. Lodish. Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals. J. Biol. Chem. 276: 39404 - 39410 (2001)

Ghaffari, S., C. Kitidis, M. D. Fleming, H. Neubauer, K. Pfeffer, and H. F. Lodish. Erythropoiesis in the Absence of Janus-kinase 2: BCR-ABL Induces Red Cell Formation in JAK2-/- Progenitors. Blood 98: 2948-2957 (2001)

Socolovsky, M., H-S. Nam, M.D. Fleming, V. H. Haase C. Brugnara and H. F. Lodish Ineffective Erythropoiesis in Stat5a-/-5b-/- mice due to decreased survival of early erythroblasts Blood 98: 3261 - 3273 (2001)

Blobe, G. C., X. Liu, S. Fang, T. How, and H. F. Lodish A novel mechanism for regulating Transforming Growth Factor ?signaling: Functional modulation of Type III TGF-?receptor expression through interaction with the PDZ domain protein, GIPC J. Biol. Chem. 276: 39608 - 39617 (2001)

Huang, L. J-S., S. N. Constantinescu and H. F. Lodish The N-terminal Domain of Janus Kinase 2 is Required for Golgi Processing and Cell Surface Expression of Erythropoietin Receptor. Mol. Cell 8: 1- 20 (2001)



Back to top

Sbodio, J., H. Lodish, and N-W Chi. Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 and IRAP. Biochem. J 361: 451 - 459 (2002)

Zhao, X., S. Ghaffari, H. Lodish, V. N. Malashkevich and P. S. Kim. Structure of the Bcr-Abl Oncoprotein Oligomerization Domain Nature Structural Biology 9: 117 - 120 (2002)

Ruan, H., N. Hacohen, T. R. Golub, L. Van Parijs and H. F. Lodish. Tumor necrosis factor-a suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: Nuclear Factor-kB activation by TNF-a is obligatory. Diabetes. 51: 1319 - 1336 (2002)

Stahl, A., Evans, J., Patel, S., D. Hirsch, and H. F. Lodish. Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. Devel. Cell 2: 477 - 488 (2002)

Pandey, A., N. Ibarrola, I. Kratchmarova , M. Fernandez, S. Constantinescu, O. Ohara, S. Sawasdikosol , H. F. Lodish, and M. Mann. A novel Src homology 2 domain-containing molecule, Src-Like Adapter Protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. J. Biol. Chem. 277: 19131 - 19138 (2002).

Kratchmarova, I., D. E. Kalume, B. Blagoev, P. E. Scherer, A. V. Podtelejnikov, H. Molina, P. E. Bickel, J. S. Andersen, M. M. Fernandez, J. Bunkenborg, P. Roepstorff, K. Kristiansen, H. F. Lodish, Matthias Mann, and A. Pandey. A Proteomic Approach for Identification of Secreted Proteins During the Differentiation of 3T3-L1 preadipocytes to Adipocytes Molecular and Cellular Proteomics 1: 213 - 222 (2002)

Tsao, T-S, H. Lodish, and J. Fruebis. ACRP30, a new hormone controlling fat and glucose metabolism. E. Jour. Pharm 440: 213 – 221. (2002)

Schiemann, W., G. C. Blobe, D. Kalume, A. Pandey, and H. F. Lodish. Context-specific effects of Fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion: Induction of Fibulin-5 expression by TGF-b and effects on protein kinase activation . J. Biol. Chem. 277: 27367 - 27377 (2002).

Tsao, T-s, H. E. Murrey, C. Hug, D. H Lee, and H. F. Lodish. Oligomerization State-Dependent Activation of NF-kB Signaling Pathway by Acrp30. J. Biol. Chem. 277: 29359-2962.

Pandey, A., B. Blagoev, I. Kratchmarova, M. Fernandez, M. Nielsen, T. Kristiansen, O. Ohara, A. Podtelejnikov, S. Roche, H. F. Lodish, and M. Mann. Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. Oncogene. 21: 8029 - 8036 (2002)

Ruan, H., P. D. G. Miles, C. M. Ladd, K. Ross, T, R. Golub, J. M. Olefsky and H. F. Lodish. Profiling Gene Transcription in vivo Reveals Adipose Tissue as an Immediate Target of TNF-a: Implications for Insulin Resistance. Diabetes. 51: 3176-3188 (2002)

Hug, C. and H. F. Lodish. Diabetes, Obesity, and Acrp30/ Adiponectin. Biotechniques 33: 654 - 658 (2002)

Brisken, C., M. Socolovsky, H. F. Lodish, and R. A. Weinberg. The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium. Proc. Natl. Acad. Sci. USA 99: 14241 - 14245 (2002)

Chen, C-Z; M. Li, D. de Graph, S, Monti, B. G–ttgens, M.-J. Sanchez, E. S Lander, T. R Golub, A, R. Green,, and H. F Lodish. Identification of Endoglin as a novel functional marker that defines long-term repopulating hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 99: 15468 - 15473 (2002)

Joost H.G., G.. I. Bell, J. D. Best, M. J. Birnbaum, M. J. Charron, Y. T. Chen, H. Doege, D. E. James, H. F. Lodish, K. H. Moley, J. F. Moley, M. Mueckler, S. Rogers, A. Schurmann, S. Seino S, B. Thorens. Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am J Physiol Endocrinol Metab 282:E974 - 976 (2002)

Thomas, E., T-s Tsao, A, Saha, H. E. Murrey, C.- c. Zhang, S. I. Itani, H. F. Lodish, and N. Ruderman. Enhancement of muscle fatty acid oxidation by globular domain of ACRP30: inactivation of Acetyl-CoA carboxylase and stimulation of AMP-activated protein kinase. Proc. Natl. Acad. Sci. USA 99: 16309-16313 (2002)



Back to top

Ghaffari S., L. J. S. Huang, J. Zhang and H. F. Lodish. Erythropoietin Receptor Signaling Processes, in "Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology", Graham Molineux, MaryAnn Foote, and Steven Elliott, editors, Birkhauser Publishing, (2003) (in the press)

Kettler, R., C. S. Moghraby, J. G. Hsiao, O. Sandra, H. F. Lodish, and U. Klingm¸ller. The cytokine-inducible SH2 domain containing protein CIS negatively regulates signaling by promoting apoptosis in erythroid progenitor cells. J. Biol. Chem. 278: 2654 - 2660 (2003)

Bogan, J., N. Hendon, A. McKee, T-s Tsao, and H.F. Lodish Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature 425: 727 – 733 (2003)

Ruan, H., H. J. Pownall, and H. F. Lodish. Troglitazone antagonizes TNF-a-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kB J. Biol. Chem. 278: 28181 - 28192 (2003)

Xiao, Z., R. Latek, and H. F. Lodish. An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity Oncogene. 22:1057 - 1069 (2003)

Ruan, H. and H. F. Lodish. Insulin Resistance in Adipose Tissue: Direct and Indirect Effects of Tumor Necrosis Factor-a. Cytokine and Growth Factor Reviews 14: 447-455 (2003)

Gimeno, R. E., A. Ortegon,. S. Patel, S. Punreddy, P. Ge, Y. Sun, H. F. Lodish, and A. Stahl. Identification of a Heart-specific Fatty Acid Transport Protein J. Biol. Chem. 278: 16039 - 16044 (2003)

Zhang, J., M. Socolovsky, A. W. Gross, and H. F. Lodish. Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood 102: 3938 - 3946 (2003)

Tsao, T-s., E. Tomas, H. E. Murrey, C. Hug, D. H. Lee, N. B. Ruderman, J. E. Heuser, and H. F. Lodish. Role of Disulfide Bonds in Acrp30/Adiponectin Structure and Signaling Specificity: Different Oligomers Activate Different Signal Transduction Pathways. J. Biol. Chem. 278: 50810 - 50817 (2003).

Ghaffari, S., Z. Jagani, C. Kitidis, H. F. Lodish and R. Khosravi-Far. Cytokines and BCR-ABL Mediate Suppression of TRAIL-Induced Apoptosis through Inhibition of FOXO3a Transcription Factor. Proc. Natl. Acad. Sci. USA 100: 6523 - 6528 (2003).

Xiao, Z., A. M. Brownawell, I. G. Macara and H. F. Lodish. A novel nuclear export signal in Smad1 is essential for its signaling. J. Biol. Chem. 278: 34245 - 34252 (2003)

Gimeno, R. E., D. J. Hirsch, S. Punreddy, Y. Sun, A. M. Ortegon, H. Wu, T. Daniels, A. Stricker-Krongrad, H. F. Lodish, and A. Stahl. Targeted Deletion of Fatty Acid Transport Protein-4 Results in Early Embryonic Lethality. J. Biol. Chem. 278: 49512 – 49516 (2003)

Constantinescu, S. T. Keren, W. P. Russ, I. Ubarretxena-Belandia, Y. Malka, K. Kubatzky, D. M. Engelman, H. F. Lodish and Y. I. Henis. The Epo Receptor Transmembrane Domain Mediates Complex Formation with Viral Anemic and Polycythemic gp55 Proteins J. Biol. Chem. 278: 43755 - 43763 (2003)

Ruan, H., M. Zarnowski, S. Cushman, and H. F. Lodish. Standard isolation of primary adipose cells from mouse epididymal fat pads induces inflammatory mediators and down-regulates adipocyte-genes. J. Biol. Chem. 278: 47585 - 47593 (2003)

Choong, M. L., A. Tan, B. Luo, and H. F. Lodish A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells FEBS Letters 550: 155 – 162 (2003)

Chen, C-Z., L. Li, M. Li, and H. F Lodish The Endoglin(Positive) Sca-1(Positive) Rhodamine(Low) phenotype defines a near homogeneous population of long–term repopulating hematopoietic stem cells. Immunity 19: 525 - 533 (2003)



Back to top

Zhang, C-C and H. F. Lodish. Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells Blood 103: 2513 - 2521 (2004)

Lodish, H. F., A. Berk, P. Matsudaira, C. Kaiser, M. Krieger, M. Scott, L. Zipursky, and J. E. Darnell. Molecular Cell Biology, 5th ed. Scientific American Press, N.Y. (2004).

Chen, C-Z., L. Li, H. F. Lodish, and D. P. Bartel. MicroRNAs Modulate Hematopoietic Lineage Differentiation. Science 303, 83-86 (2004)

Tsao, T-s, C. Hug, and H. F. Lodish. Adipokines: Regulators of Metabolic Integration and Energy Metabolism. Chapter 65 in Diabetes Mellitus: A Fundamental and Clinical Text. Third Edition. D. LeRoith, S. Taylor, and J. Olefsky eds. Lippincott Williams and Wilkins pp 963 - 978 (2004)

Luo, B., A. Heard, and H. F. Lodish. siRNA production by enzymatic engineering of DNA (SPEED) Proc. Natl. Acad. Sci. USA 101: 5494 - 5499 (2004)

Ruan H and H. F. Lodish. Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines. Curr Opin Lipidol. 15(3):297-302 (2004).

Marszalek, J. R., C. Kitidis, A. Dararutana and H. F. Lodish Acyl CoA Synthetase 2 (ACS2) Over-expression Enhances Fatty Acid Internalization and Neurite Outgrowth J. Biol. Chem. 279: 23882 - 23891 (2004).

Kim, J., R. E. Gimeno, T. Higashimori, H-J. Kim, H. Cho, ,S. Punreddy, R. Mozell, G. Tan, A. Stricker-Krongrad, D. J. Hirsch, J. J. Fillmore, Z-X. Liu, J. Dong, G. Cline, A. Stahl, H. F. Lodish, and G. I. Shulman. Inactivation of Fatty Acid Transport Protein 1 Prevents Fat-Induced Insulin Resistance In Skeletal Muscle J. Clinical Investigation 113: 756 - 763 (2004).

Choong, M. L., B. Luo, and H. F. Lodish. Microenvironment- driven changes in the expression profile of hematopoietic cobblestone area- forming cells. Ann. Hematol. 83:160–169 (2004)

Choong, M. L., Y. P., Yonga, A. Tana, B. Luo, and H. F. Lodish. LIX: a chemokine with a role in hematopoietic stem cells maintenance. Cytokine 25: 239 – 245 (2004).

Zhang, J., and H. F. Lodish. Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors. Blood (2004)

Hug, C., J. Wang, N. Ahmad, J. Bogan, T.-S. Tsao, and H. F. Lodish. T-cadherin is a receptor for hexameric and high molecular weight forms of Acrp30/adiponectin. Proc. Natl. Acad. Sci. USA (2004)

Tong, W., and H. F. Lodish. Lnk inhibits Tpo/mpl signaling and Tpo-mediate megakaryocytopoiesis. J. Exp. Med (2004).

Wong, G., J. Wang, C. Hug, T.-S. Tsao, and H. F. Lodish. A family of Acrp30/adiponectin structural and functional paralogs. Proc. Natl. Acad. Sci. USA (2004)




Back to top

Marszalek, J., C. Kitidis, C. DiRusso and H. F. Lodish Long-chain Acyl CoA Synthetase 6 preferentially promotes DHA metabolism. J. Biol. Chem. 280: 10817 - 10826 (2005).

Chen, C-Z., and H. F. Lodish. microRNAs as regulators of mammalian hematopoiesis. Semin. Immunol. 17: 155–165 (2005)

Hug, C. and H. F. Lodish. The role of the adipocyte hormone Adiponectin in cardiovascular disease. Current Opinions in Pharmacology 5: 129 - 134 (2005)

Zhang, C-C. and H. F. Lodish. Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion. Blood 105: 4314 - 4320 (2005).

Zhang, J. and H. F. Lodish. Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo. . Proc. Natl. Acad. Sci. 102: 14605- 14610 (2005) .

Marszalek, J., and H. F. Lodish. Docosahexaenoic Acid, Fatty Acid Interacting Proteins, and Neuronal Function: Breastmilk and Fish are Good For You. Ann. Rev. Cell. Dev. Biol (2005)

Tong, W., J. Zhang, and H. F. Lodish. Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood 105: 4604 - 4612 (2005).
Lu, X., R. Levine, W. Tong, G. Wernig, Y. Pikman, S. Zarnegar, D. G. Gilliland and H. F. Lodish. Expression of a Type I Cytokine Receptor is Required for JAK2V617F-mediated Transformation of Hematopoietic Cells. Proc. Natl. Acad. Sci. USA 102: 14605 ?14610 (2005) .

Ruan, H. and H. F. Lodish. Dyslipidemia and Atherosclerosis: mechanism, transcriptional regulation, consequences, and treatment. Lipid Disorder Updates in the press (2005)


Back to top

Zhao, W., C. Kitidis, M. D. Fleming, H. F. Lodish, and S. Ghaffari Activated AKT Induces Erythroid Cell Maturation Through GATA-1-Dependent and Independent Mechanisms Blood 107: 907 ?915 (2006).

Ghaffari, S., C. Kitidis, W. Zhao, D. Marinkovic, M. D. Fleming, B. Luo, J. Marszalek., and H. F. Lodish. AKT induces erythroid cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid cell differentiation Blood 107: 1888 ? 1891 (2006)

Gross, A., and H. F. Lodish. Cellular Trafficking and Degradation of Erythropoietin and NESP. J Biol Chem. 2006 Jan 27;281(4):2024-32. Epub 2005 Nov 11

Zhang, C-C., A. D. Steele, S. L. Lindquist, H. F. Lodish. Prion protein is expressed on long-term repopulating hematopoietic stem cells and is necessary for their self-renewal. . Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2184-9. Epub 2006 Feb 7..

Zhang, C-C,. M. Kaba, G. Ge, K. Xie, W. Tong, C. Hug and H. F. Lodish. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nature Medicine 12, 240-245 (2006)

Um, M, and H. F. Lodish. Antiapoptotic effects of Erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both STAT5 and AKT pathways.J. Biol. Chem. 281: 5648 - 5656.
Lu, X., A. Gross, and H. F. Lodish. Active Conformation of the Erythropoietin Receptor: Random and Cysteine-Scanning Mutagenesis of the Extracellular, Juxtamembrane, and Transmembrane Domains.J. Biol. Chem.281: 7002 - 7011.
Hubbard, B., S. H. Doege, S. Punreddy, H. Wu, X. Huang, V. Kaushik, R. L. Mozell, J. Byrnes, A. Stricker-Krongrad, J. Chou, L. A. Tartaglia, H. F. Lodish, A. Stahl, and R. E. Gimeno Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology. 2006 Apr;130(4):1259-69.
Rao, P., R. Kumar, M. Farkhondeh, S. Baskerville, and H. F. Lodish. Myogenic factors that regulate expression of muscle specific microRNAs. Proc. Natl. Acad. Sci. USA 103: 8721- 8726 (2006)
Tong, W., R. Sulahian, A. W. Gross, N. Hendon, H. F. Lodish, and L. J-s Huang. The membrane proximal region of the thrombopoietin receptor (TpoR) confers its high surface expression by JAK2- dependent and independent mechanisms. J. Biol. Chem. 281:38930 - 38940 (2006)
Wong, K., and H. F. Lodish. A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits J. Biol. Chem. 281: 36434 - 36442 (2006).


Back to top

Scott, L., W. Tong, R. L. Levine, M. A. Scott, P. A Beer, M. R. Stratton, P. A. Futreal, W. Eber, M. F. McMullin, C. N. Harrison, W. M. Erber, A. J. Warren, D. G. Gilliland, H. F. Lodish, A. R. Green. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N. England J. Med. 356: 459 - 68 (2007).
Um, M. A. Gross, and H. F. Lodish. A homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y cells. Cell Signaling 19: 634 -645 (2007)
Tong, W., Ibarra, Y. M., and H. F. Lodish. Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal. Exp Hematol. 35(9):1447-55. (2007).
Eshghi, S., M. G. Vogelezang, R. O. Hynes, L. G. Griffith, and H. F. Lodish. Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J Cell Biol.177(5):871-80. (2007).
Zhou, B., S. Wang, C, Mayr, D.P. Bartel, and H. F. Lodish. miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc. Natl. Acad. Sci. USA 104: 7080 -7085 (2007)
Shuga, J., J. Zhang, L. D. Samson, H. F. Lodish, and L. Griffith. In vitro erythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds Proc Natl Acad Sci U S A. 104(21):8737-42. (2007).
Zhang, J., Y. Liu, C. Beard, D. A. Tuveson, R. Jaenisch, T. E. Jacks and H. F. Lodish. Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways. Blood. 109(12):5238-41. (2007).
Liao, M.-J., C. Zhang, B. Zhou, M. Kaba, A. Gifford, F. Reinhardt, S. A. Mani, H. F. Lodish, and R. A. Weinberg. Enrichment of a population of mammary gland cells that forms mammospheres and has in vivo repopulating activity. Cancer Res. 67(17):8131-8. (2007).
Zhang, J., and H. F. Lodish. Endogenous K-ras signaling in erythroid differentiation. Cell Cycle. 6(16):1970-3. (2007).
Hattangadi, S., and H. F. Lodish. Regulation of Erythrocyte Lifespan: Is the Clock Set by ROS? J Clin Invest. (Commentary) 117(8):2075-7. (2007).


Back to top

Zhang, C-C,. M. Kaba, S. Iizuka, HD Huynh, and H. F. Lodish. Angiopoietin-like protein 5 and IGFBP-2 stimulate ex vivo expansion of human hematopoietic stem cells. Blood 111: 3415 - 3423 (2008)
Huynh, HD., S. Iizuki, M. Kaba, O. Kirak, J. Zheng, H. F. Lodish, and C. C. Zhang. IGFBP2 secreted by a tumorigenic cell line supports ex vivo expansion of hematopoietic stem cells. Stem Cells. 26(6):1628-35 (2008)
Wong, G.W., S. A. Krawczyk, C. Kitidis-Mitrokostas, T. Revett, R. Gimeno, and H. F. Lodish. Molecular, biochemical, and functional characterizations of C1q/TNF family members: adipose tissue-selective expression patterns, regulation by PPAR-gamma agonist, Cys-mediated oligomerizations, combinatorial associations, and metabolic functions. Biochem. J. 416(2):161-77 (2008).
Lu, X., L. Huang, and H. F. Lodish Dimerization by a cytokine receptor is necessary and sufficient for constitutive activation of JAK2V617F. J. Biol. Chem 283: 5258 - 5266 (2008).
Ji, Peng, S. Jayapal, and H. F. Lodish Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2. Nature Cell Biology 10: 314 - 321 (2008)
Lodish, H.F., B. Zhou, G. Liu, and C.-Z. Chen. Micromanaging the Immune System by microRNAs. Nature Reviews in Immunology. 8: 120 - 130 (2008)
Zhang, CC and H. F. Lodish. Cytokine Regulation of Hematopoietic Stem Cell Function. Current Opinion in Hematoogy. 15(4):307-11 (2008)
Herrlich, A., E. Kleinman, J. Fu, C. Sadegh, and H. F. Lodish Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes. FASEB Journal. 22: 4281-4295 (2008).
Lodish, H. F., A. Berk, C. Kaiser, M. Krieger, M. Scott, A. Bretscher, H. Ploegh, and P. Matsudaira. Molecular Cell Biology, 6th ed. W. H.. Freeman and Company, N.Y. (2008).


Back to top

Lodish, H. F., S. Ghaffari, M. Socolovsky, W. Tong, and J. Zhang. Intracellular Signaling by the Erythropoietin Receptor in Erythropoiesis and Eythropoietins (Second Edition) Editors: G Molineux, MA Foote, and SG Elliott. Birkhauser 155-174 (2009).
Wong, G.W., S. A. Krawczyk, C. Kitidis-Mitrokostas, G. Ge, E. Spooner, C. Hug, R. Gimeno, and H. F. Lodish. Identification and characterization of CTRP9, a novel secreted glycoprotein from adipose tissue that reduces serum glucose in mice and forms heterotrimers with Adiponectin. FASEB J. 23(1):241-58(2009).
Zhang, Y. L., M. L. Radhakrishnan, X. Lu, A. Gross, B. Tidor, and H. F. Lodish. Symmetric Signaling by an Asymmetric 1 Erythropoietin: 2 Erythropoietin Receptor Complex. Mol Cell. 33(2):266-74 (2009).
Xie, H., B. Lim, and H. F. Lodish. MicroRNAs Induced during Adipogenesis That Accelerate Fat Cell Development Are Downregulated in Obesity. Diabetes. 58:1050-1057 (2009).
Le, MT., C. The, S-S Ng, H. Xie, B. Zhou, V. Korzh, H. F. Lodish, and B. Lim. MicroRNA-125b is a novel negative regulator of p53. Genes and Development 23:862-876 (2009).
Zhang, J., , J. Wang, Y. Liu, H. Sidik, K. Young, H. F. Lodish, and M. Fleming. Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the targets for final leukemic transformation. Blood 113:1304-1314 (2009).
Wood, A.. D., E. Chen, I. Donaldson, S. Hattangadi, K. Burke, D. Miranda-Saavedra, H. F. Lodish, A. R. Green, and B. Gottgens. Id1 promotes expansion and survival of primary erythroid cells and is a direct target of JAK2V617F-STAT5 signalling. Blood. 114(9):1820-30 (2009).
Le, MT, H. Xie, B. Zhou, P. Chia, M. Um, G.Udolph, H.Yang, B. Lim and H. Lodish. microRNA-125b Promotes Neuronal Differentiation in Human Cells by Repressing Multiple Targets. Mol Cell Biol. in the press (2009).
Xie, H., Sun, L. and H.F. Lodish. Targeting microRNAs in obesity. Expert Opin Ther Targets. in the press (2009).
Rao, P., Y. Toyama, R. Chiang, S. Gupta, M. Bauer, R. Medvid, F. Reinhardt, R. Liao, M. Krieger, R. Jaenisch, H. F. Lodish, and R. Blelloch. Loss of cardiac microRNA regulation leads to dilated cardiomyopathy and heart failure. Circ Res. in the press (2009).
Kotani, A., D. Ha, J. Hsieh, P. Rao, D. Schotte, M. den Boer, S. Armstrong, and H. F. Lodish. miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 Acute Lymphocytic Leukemia cells and exerts cooperative effects with miR-221. Blood. in the press (2009).
Duraisingh, M. and H. F. Lodish. Sickle cell microRNAs inhibit the malaria parasite. Cell Host and Microbe. in the press (2009).
Ji, P. and H. F. Lodish. Rac GTPases play multiple roles in erythropoiesis. Haematologica. in the press (2009).
Sieff, C., L. B. Merida-Long, J. Yang, and H. F. Lodish. Pathogenesis of the Erythroid Failure in Diamond Blackfan Anemia. British J of Haematology. Submitted (2009).
Flygare, J., and H. F. Lodish. Glucocorticoids stimulate self-renewal of BFU-Es, increase production of CFU-E erythroid progenitors, and enhance terminal erythroid differentiation. Blood. Submitted (2009).
Hattangadi, S., K. Burke, and H.F. Lodish. Homeodomain-interacting protein kinase 2 is essential for terminal fetal liver erythroid proliferation and differentiation. Blood. Submitted (2009).
Ramirez, T., P. Ji, S. Jayapal, H. F. Lodish and M. Murata-Hori. Mammalian erythroblast enucleation is achieved by a novel mechanism different from that of cytokinesis. Nature. Submitted (2009).


Back to top

Sieff CA, Yang J, Merida-Long LB, Lodish HF. Pathogenesis of the erythroid failure in Diamond Blackfan anaemia. (Br J Haematol. 2010 Feb;148(4):611-22. Epub 2009 Dec 1. (2010).
Zhang J, Lee EY, Liu Y, Berman SD, Lodish HF, Lees JA. pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis. Cell Cycle. 2010
Ji P, Lodish HF. Rac GTPases play multiple roles in erythropoiesis. Haematologica. 2010
Hattangadi SM, Burke KA, Lodish HF. Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation. Blood. 2010
Kotani A, Ha D, Schotte D, den Boer ML, Armstrong SA, Lodish HF. A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells. Cell Cycle. 2010
Chou S, Lodish HF. Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells. Proc Natl Acad Sci U S A. 2010
Rao PK, Missiaglia E, Shields L, Hyde G, Yuan B, Shepherd CJ, Shipley J, Lodish HF. Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells. PFASEB J. 2010
Sun Y, Lodish HF. Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration. PLoS One. 2010
Ji P, Yeh V, Ramirez T, Murata-Hori M, Lodish HF. Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts. Haematologica. 2010
Jayapal SR, Lee KL, Ji P, Kaldis P, Lim B, Lodish HF. Down-regulation of Myc is essential for terminal erythroid maturation. J Biol Chem. 2010
Bousquet M, Harris MH, Zhou B, Lodish HF. MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci U S A. 2010


Back to top

` `

Khoury M, Drake A, Chen Q, Dong D, Leskov I, Fragoso MF, Li Y, Iliopoulou BP, Hwang W, Lodish HF, Chen J Mesenchymal Stem Cells Secreting Angiopoietin-Like-5 Support Efficient Expansion of Human Hematopoietic Stem Cells Without Compromising Their Repopulating Potential. Stem Cells Dev. 2011
Flygare J, Rayon Estrada V, Shin C, Gupta S, Lodish HF. HIF-1 {alpha} synergizes with glucocorticoids to promote BFU-E progenitor self-renewal. Blood. 2011
Zhang L, Flygare J, Wong P, Lim B, Lodish HF. miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1. Genes Dev. 2011
Sankaran VG, Menne TF, Scepanovic D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci U S A. 2011
Bousquet M, Lodish HF. MicroRNAs: the primary cause or a determinant of progression in leukemia? Expert Rev Hematol. 2011
Ji P, Murata-Hori M, Lodish HF. Formation of mammalian erythrocytes: chromatin condensation and enucleation. Trends Cell Biol. 2011
Sun L, Xie H, Mori MA, Alexander R, Yuan B, Hattangadi SM, Liu Q, Kahn CR, Lodish HF. Mir193b-365 is essential for brown fat differentiation. Nat Cell Biol. 2011

Drake, A., M. Khoury, I. Leskov, B. Iliopoulou, M. Fragoso, H. Lodish, and J. Chen Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rgamma-/- (NSG) mice. PLoS ONE; 6: e18382.

Dang, M., K. Dubbin, A. D’Aiello, M. Stopinska, H. Lodish, and A. Herrlich EGF-ligand cleavage is regulated on the substrate level in a cell- specific manner. J. Biol. Chem. 286:17704-13 (2011).

Hattangadi, S., P. Wong, L. Zhang, J. Flygare, and H. Lodish From stem cell to red cell: Regulation of erythropoiesis at multiple levels by multiple proteins, RNAs and chromatin modifications. Blood 118: 6258 - 6268 (2011).

Alexander, R., H. Lodish, and L. Sun MicroRNAs as therapeutic targets for mitigating obesity. Expert Opinion on Therapeutic Targets 15: 623 - 636 (2011)

Le, M. T. N., N. Shyh-Chang, S. L. Khaw, M. Chin, C. Teh, J. Tay, E. O’Day, V. Korzh, H. Yang, A. Lal, J. Lieberman, H. Lodish, and B. Lim Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs PLOS Genetics 7: e1002242 (2011)

Bousquet, M. and H. Lodish. MicroRNAs: the primary cause or a determinant of progression in leukemia? Expert Review of Hematology 4: 121 - 123 (2011)

Wong, P., S. Hattangadi, A. Cheng, G. Frampton, R. A. Young, and H. Lodish. Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood 118: e128 – e138  (2011).

Ji, P., M. Murata-Hori, and H. Lodish, Formation of mammalian erythrocytes: Chromatin condensation and enucleation. Trends in Cell Biology 21: 409-415 (2011).

Hu, W., B. Yuan, J. Flygare, and H. Lodish Long non-coding RNA- mediated antiapoptotic activity in murine erythroid terminal differentiation. Genes and Development 25: 2573- 2578 (2011).


Back to top

` `


Ji, P. and H. Lodish Ankyrin and Band 3 Differentially Affect Expression of Membrane Glycoproteins But Are Not required for Erythroblast Enucleation Biochem Biophys Res Comm 417: 1188 – 1192 (2012).

Wang, J., T. Ramirez, P. Ji, S. Jayapal, H. F. Lodish and M. Murata-Hori. Mammalian erythroblast enucleation requires PI(3)K-dependent cell polarization. J. Cell. Science. 125: 340 - 349 (2012)

Zhang, L., Sankaran, V. and H. Lodish MicroRNAs in normal myeloerythropoiesis. Leukemia in the press (2012)

Sun, L., C. Trapnell, L. Goff, R. Alexander, A. Lo, M. Kellis, H. Lodish, and J. Rinn. Long noncoding RNAs regulate adipogenesis. Developmental Cell submitted (2012)

Chou, S., J. Flygare, and H. Lodish. Fetal Hepatic Progenitors Support Long-term Expansion of Hematopoietic Stem Cells. Blood submitted. (2012)

Zhang, L., Sankaran, V. and H. Lodish. MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Leukemia 26: 2310-2316. (2012).

Sankaran, V., L. S. Ludwig, E. Sicinska, J. Xu, D. E. Bauer, J. C. Eng, H. C. Patterson, R. A. Metcalf, Y. Natkunam, S. H. Orkin, P. Sicinski, E. S. Lander, and H. F. Lodish. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes and Development 26: 2075-2087. (2012)

Bousquet, M., D. Nguyen, C. Chen, L. Shields, and H. Lodish. miR-125b transforms myeloid progenitors by repressing multiple mRNA targets. Haematologica 97: 1713-1721. (2012).

Liu, Q, B. Yuan, K. Lo, H. Patterson, Y. Sun, and H. Lodish. Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism. PNAS 109: 14568 - 14573. (2012).

Hu, W., J. Alvarez-Dominguez, and H. Lodish. Regulation of Mammalian Cell Differentiation by Long Noncoding RNAs. EMBO Reports 13: 971 - 983. (2012).

Duraisingh, M. and H. Lodish. Sickle cell microRNAs inhibit the malaria parasite. Cell Host and Microbe 12: 127-128. (2012).

Lodish, H. Reflections, Translational Control of Protein Synthesis: The Early Years. J. Biol. Chem. 287: 36528 - 36535. (2012).

Lodish, H. F., and N. Fedoroff. Retrospective: Norton Zinder (1928-2012) Science 335:6074 (2012)

Lodish, H. F., A. Berk, C. Kaiser, M. Krieger, A. Bretscher, H. Ploegh, A. Amon, and M. Scott, Matsudaira. Molecular Cell Biology, 7th ed.  W. H.. Freeman and Company, N.Y. (2012).


Back to top

` `

Alvarez-Dominguez, J., W. Hu, and H. Lodish. Regulation of Eukaryotic Cell Differentiation by Long Noncoding RNAs. The Molecular Biology of Long Non-coding RNAs. J. Coller and A. Khalil, eds., Springer Science, in the press. (2013).

Chen, C., D. Garcia-Santos, Y. Ishikawa, A. Seguin, L. Li, K. Fegan, G. Hildick-Smith, D. Shah, J. D. Cooney, W. Chen, M. King, Y. Yien, I. Schultz, H. Anderson, A. Dalton, M. Freedman, P. Kingsley, J. Palis, S. Hattangadi, H. Lodish, D. Ward, J. Kaplan, T. Maeda, P. Ponka, and B. Paw. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metabolism 17:343 - 352. (2013).

Lo, K., A. Labadorf, .L Sun, N. Kennedy, R. Davis, H. Lodish, and E. Fraenkel. Comprehensive analysis of four in vitro insulin resistance models and their physiological relevance to adipose insulin resistance resulting from diet-induced obesity. Cell Reports in the press. (2013).

Okuyama, K., T. Ikawa, R. Harnprasopwat, J. Lu, R. Yamashita, D. Ha, T. Toyoshima, B. Chanda, T. Kawamata, K. Yokoyama, B. Gertner, S. Wang, K. Ando, H. Lodish, A. Tojo, H. Kawamoto, and A. Kotani. miR-126-mediated control of cell fate in B cell-myeloid progenitors as a potential alternative to transcriptional factors. PNAS in the press. (2013).

Sun, L., L. Goff, C. Trapnell, R. Alexander, A. Lo, E. Hacisuleyman, M. Savageau, B. Tazon-Vega, D. Kelley, D. Hendrickson, B. Yuan, M. Kellis, H. Lodish, and J. Rinn. Long noncoding RNAs regulate adipogenesis. PNAS 110:3387 - 3392. (2013).

Chou, S., J. Flygare, and H. Lodish. Fetal Hepatic Progenitors Support Long-term Expansion of Hematopoietic Stem Cells. Experimental Hematology 41: 479-490. (2013).

Zhang, L., L. Prak, J. Flygare, V. R. Estrada, P. Thiru, B. Lim, and H. F. Lodish. Zfp36l2 is required for self-renewal of early erythroid BFU-E progenitors. Nature 499, 92-96. (2013).

Dang, M., N. Armbruster, M. Miller, E. Cermeno-Blondet, M. Hartmann, G. Bell, D. Root, D. Lauffenburger, H. Lodish, and A. Herrlich. Regulated ADAM17 dependent EGF family ligand release through separate and distinct signaling pathways without increase of protease activity. PNAS 110: 9776 - 9781. (2013).

Trajkovski, M. and Lodish, H. MicroRNA networks regulate development of brown adipocytes. Trends Endocrinology and Metabolism in the press. (2013).

Shi, J.,B. Yuan, W. Hu, and H. Lodish. JAK2-V617F enhances red cell production by triggering CFU-E self-renewal. J. Clin. Invest. submitted (2013).

Chen, C., and H. Lodish. E2F binding partner TFDP2 regulates terminal erythroid differentiation by modulating cell cycle progression. Blood submitted (2013).

Pishesha, N., P. Thiru, J. Shi, J. Eng, V. Sankaran, and H. Lodish. Transcriptional divergence and conservation of human and mouse erythropoiesis. Blood submitted (2013).

Alvarez-Dominguez JR, Hu W, Yuan B, Shi J, Park SS, Gromatzky AA, van Oudenaarden A, Lodish HF. Global discovery of erythroid long non-coding RNAs reveals novel regulators of red cell maturation. Blood 2013 Nov 7.